Results 71 to 80 of about 33,100 (295)
Advanced Science, EarlyView.The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li +6 more
wiley +1 more source
N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol
Molecules, 2015 Resveratrol is a natural polyphenol with many interesting biological activities. Its pharmacological exploitation in vivo is, however, hindered by its rapid elimination via phase II conjugative metabolism at the intestinal and, most importantly, hepatic ...
Andrea Mattarei +4 more
doaj +1 more source
Engineering Prodrug Nanomedicine for Cancer Immunotherapy
Advanced Science, 2020 Immunotherapy has shifted the clinical paradigm of cancer management. However, despite promising initial progress, immunotherapeutic approaches to cancer still suffer from relatively low response rates and the possibility of severe side effects, likely ...
Bin Yang +4 more
doaj +1 more source
Prodrugs: bridging pharmacodynamic/pharmacokinetic gaps
, 2009 In this mini review, prodrugs are discussed with a focus on their pharmaceutical, pharmacokinetic, and pharmacodynamic objectives, as well as on the resulting therapeutic benefits.
Bernard Testa, Testa, B., Testa B
core +1 more source
Advanced Science, EarlyView.An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan +7 more
wiley +1 more source
Prodrugs in Cardiovascular Therapy
, 2008 Prodrugs are biologically inactive derivatives of an active drug intended to solve certain problems of the parent drug such as toxicity, instability, minimal solubility and non-targeting capabilities.
Chady B. Sarraf +2 more
core +2 more sources
Prodrugs activated by reactive oxygen species for use in the treatment of inflammatory diseases and cancer [PDF]
, 2018 Prodrugs activated predominantly or exclusively in inflammatory tissue, more particularly prodrugs of methotrexate and derivatives thereof, which are selectively activated by Reactive Oxygen Species (ROS) in inflammatory tissues associated with cancer ...
Bondebjerg, Jon +3 more
core
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Nanoscale Buried Interface Control in Silicone Hydrogels Enables a Biointerface Engineering Platform
Advanced Science, EarlyView.A hydrophilic coating with controllable nanoscale thickness is applied to commercial silicone hydrogel contact lenses. By combining comprehensive multi‐modal three‐dimensional characterization with an advanced algorithm, the thickness and chemical information of these multilayered structures are resolved.
Po‐Hsiang Chen +5 more
wiley +1 more source
Advances in oral delivery of anti-cancer prodrugs
, 2016 Introduction: Most anticancer drugs have poor aqueous solubility and low permeability across the gastrointestinal tract. Furthermore, extensive efflux by P-glycoproteins (P-gp) in the small intestine also limits the efficient delivery of anticancer drugs
Sanyog Jain (831152) +1 more
core +1 more source