Results 81 to 90 of about 73,540 (330)
Acta Pharmaceutica Sinica BThe self-assembly prodrugs are usually consisted of drug modules, activation modules, and assembly modules. Keeping the balance between efficacy and safety by selecting suitable modules remains a challenge for developing prodrug nanoassemblies.
Shuo Wang +10 more
doaj +1 more source
Synthesis and kinetic studies of mutual azo prodrugs of 5-aminosalicylic acid with sulfamethoxazole and trimethoprim as models for colon targeting [PDF]
المجلة العراقية للصيدلة, 2010 In this study, two mutual azo prodrugs were synthesized for colon targeting in a treatment of colonic diverticular disease. The first was synthesized by coupling sulfamethoxazole with salicylic acid; the second was synthesized by coupling one mole of ...
Yasser Fakri Mustafa
doaj +1 more source
Organic Carbon Monoxide Prodrugs [PDF]
, 2017 Ongoing efforts towards the development of CO-based therapeutics have resulted in the generation of novel CO prodrugs that release CO via different triggers or stimuli.
Aghoghovbia, Robert
core
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol
Molecules, 2015 Resveratrol is a natural polyphenol with many interesting biological activities. Its pharmacological exploitation in vivo is, however, hindered by its rapid elimination via phase II conjugative metabolism at the intestinal and, most importantly, hepatic ...
Andrea Mattarei +4 more
doaj +1 more source
Engineering Prodrug Nanomedicine for Cancer Immunotherapy
Advanced Science, 2020 Immunotherapy has shifted the clinical paradigm of cancer management. However, despite promising initial progress, immunotherapeutic approaches to cancer still suffer from relatively low response rates and the possibility of severe side effects, likely ...
Bin Yang +4 more
doaj +1 more source
Clinical and Translational Radiation Oncology, 2019 Highlights • Hypoxia-activated prodrugs have yielded promising results up to phase II trials.• Implementation of hypoxia-activated prodrugs in the clinic has not been successful.• Phase III clinical trials lack patient stratification based on tumor ...
Linda Spiegelberg +10 more
semanticscholar +1 more source
Enzyme-mediated activation of prodrugs
The development of potent drugs is always a challenging task and is often complicated by the number of pharmacokinetic and formulation limitations they suffer from.
D'Agostino, Ilaria +2 more
core +1 more source
Prodrugs: bridging pharmacodynamic/pharmacokinetic gaps
, 2009 In this mini review, prodrugs are discussed with a focus on their pharmaceutical, pharmacokinetic, and pharmacodynamic objectives, as well as on the resulting therapeutic benefits.
Bernard Testa, Testa, B.
core +1 more source
Dermal and transdermal delivery: prodrugs
, 2011 Attempts to deliver drugs into and through the skin (dermal and transdermal delivery) have not been very successful because the physicochemical properties of drugs are often not optimal.
Kenneth B Sloan +2 more
core +1 more source