Results 121 to 130 of about 3,216,786 (362)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases on Live Cells [PDF]

, 2016
Jie Zhou, Xuewen Du, Cristina Berciu, Hongjian He, Junfeng Shi, Daniela Nicastro, Bing Xu   +6 more
openalex   +1 more source

Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA [PDF]

, 2020
Mu‐Sen Liu, Shanzhong Gong, Helen‐Hong Yu, Kyungseok Jung, Kenneth A. Johnson, David W. Taylor   +5 more
openalex   +1 more source

Exploration of Trichoderma reesei as an alternative host for erythritol production

Biotechnology for Biofuels and Bioproducts
Background Erythritol, a natural polyol, is a low-calorie sweetener synthesized by a number of microorganisms, such as Moniliella pollinis. Yet, a widespread use of erythritol is limited by high production costs due to the need for cultivation on glucose-
Audrey Masi, Georg Stark, Johanna Pfnier, Robert L. Mach, Astrid R. Mach-Aigner   +4 more
doaj   +1 more source

Stochastic thermodynamics of single enzymes and molecular motors

, 2010
For a single enzyme or molecular motor operating in an aqueous solution of non-equilibrated solute concentrations, a thermodynamic description is developed on the level of an individual trajectory of transitions between states.
Seifert, Udo
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Enzyme Promiscuity: Engine of Evolutionary Innovation [PDF]

, 2014
Chetanya Pandya, Jeremiah D. Farelli, Debra Dunaway‐Mariano, Karen N. Allen   +3 more
openalex   +1 more source

Gating NO Release from Nitric Oxide Synthase [PDF]

, 2012
We have investigated the kinetics of NO escape from Geobacillus stearothermophilus nitric oxide synthase (gsNOS). Previous work indicated that NO release was gated at position 223 in mammalian enzymes; our kinetics experiments include mutants at that ...
Agapie, Theodor, Gray, Harry B., Lavoie, Katherine D., Warren, Jeffrey J., Weinert, Emily E., Whited, Charlotte A., Winkler, Jay R.   +6 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Teaching Enzyme Catalysis Using Interactive Molecular Dynamics in Virtual Reality [PDF]

, 2019
Simon J. Bennie, Kara E. Ranaghan, Helen M. Deeks, Heather E. Goldsmith, Michael B. O’Connor, Adrian J. Mulholland, David R. Glowacki   +6 more
openalex   +1 more source