Results 121 to 130 of about 2,028,343 (313)

Identification of compounds with regenerative effects in the mucus of the garden snail Cornu aspersum

Biotechnology & Biotechnological Equipment
Snail mucus is a complex multicomponent mixture of proteoglycans, glycosaminoglycans, enzymes, hyaluronic acid, proteins, antimicrobial peptides, amino acids and metal ions.
Momchil Kermedchiev, Maya Guncheva, Angelina Kosateva, Maria Todorova, Valentina Lyubomirova, Lyudmila Velkova, Pavlina Dolashka, Aleksandаr Dolashki   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Lipid modification by enzymes and engineered microbes /

Lipid Modification by Enzymes and Engineered Microbes covers the state-of-the art use of enzymes as natural biocatalysts to modify oils, also presenting how microorganisms, such as yeast, can be designed.
Bornscheuer, U. T.(Uwe Theo),
core  

Structural and functional comparisons between vanadium haloperoxidase and acid phosphatase enzymes.

, 2002
The crystallographic structures of both the vanadium chloroperoxidase and bromoperoxidase enzymes have been determined with either vanadium or phosphate bound at their active site.
Littlechild, J., Garcia-Rodriguez, E., Dalby, A.R., Isupov, M.   +3 more
core   +1 more source

Lignocellulosic Enzymes Characterization and Scanning Electron Microscope Analysis on Rice Bran Surface Structure Changes [PDF]

, 2015
Rice bran was one of livestock food ingredients wit h high crude fibers contents, including cellulose and hemicelluloses. Lignocellulosic enzymes such as xylanase and cellulase functioned in degrading cellulose and ...
Al-Arif, M. Anam, Kurniati, Anita, Asmarani, One, Lamid, Mirni, Warsito, Sunaryo Hadi, Puspaningsih, Ni Nyoman Tri   +5 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Seasonal Variation in Bivalve Antioxidant Enzymes: Can they be used as indicators of heavy metal contamination? [PDF]

, 2009
Seasonal variations in the activity of several enzymes (glutathione reductase (GR), glutathione S-transferase (GST), and glutathione peroxidase (GPx)) involved in the glutathione cellular defence system were measured in whole tissues of the common New ...
Gibson, Aimee Clare
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Spatial activity mapping of ß-mannanase on soybean seeds

Scientific Reports
For farm animals the supplementation of exogenous enzymes, like ß-mannanase, to soybean-based diets is beneficial to improve feed digestibility. In order to unravel the effect of ß-mannanase on soybean meal’s cell structure, a novel imaging concept was ...
Markus Rueckel, Sven Janson, Arne Solbak, Anna Fickler   +3 more
doaj   +1 more source