Results 171 to 180 of about 23,268 (212)

Eosinophilic Otitis Media: the Aftermath of Eosinophil Extracellular Trap Cell Death

Current Allergy and Asthma Reports, 2017
Eosinophilic otitis media (EOM) is a refractory disease characterized by the accumulation of eosinophils in middle ear effusion and mucosa. We summarize current knowledge regarding the clinical characteristics and management of EOM. Although eosinophil activation in inflamed foci is involved in the pathogenesis of EOM, little is known about the fate of
Shigeharu, Ueki, Nobuo, Ohta, Masahide, Takeda, Yasunori, Konno, Makoto, Hirokawa   +4 more
openaire   +2 more sources

Eosinophil extracellular traps activate type 2 innate lymphoid cells through stimulating airway epithelium in severe asthma

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Activated eosinophils release extracellular traps (EETs), which contribute to airway inflammation in severe asthma (SA). However, the role of EETs in innate immunity has not yet been completely determined.
Youngwoo Choi, Young-Min Kim, Hee-Ra Lee, J. Mun, Soyoon Sim, Dong-Hyun Lee, D. Pham, Seung-Hyun Kim, Y. Shin, Seung-Woo Lee, Hae‐Sim Park   +10 more
semanticscholar   +1 more source

Eosinophil extracellular traps drive T follicular helper cell differentiation via VIRMA-dependent MAF stabilization in bullous pemphigoid.

Journal of Allergy and Clinical Immunology
BACKGROUND Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by the presence of pathogenic autoantibodies and a substantial influx of immune cells into skin lesions.
S. Shen, H. Fang, Xia Li, Yifan Zhou, Xin Tang, Haijun Miao, Liang Li, Jiaoling Chen, Ke Xue, Chen Zhang, Mengyang Chu, B. Pang, Yaxing Bai, Hongjiang Qiao, E. Dang, S. Shao, Gang Wang   +16 more
semanticscholar   +1 more source

Presence of eosinophil extracellular trap cell death in the affected skin of eosinophilic granulomatosis with polyangiitis

The Journal of Dermatology, 2022
AbstractEosinophil activation in tissue might be associated with disease severity. Eosinophil cytolysis, a process of active cell death, has been referred to as eosinophil extracellular trap cell death (EETosis). In the present study, the authors investigated EETosis in the affected skin of four patients with eosinophilic granulomatosis with ...
Tamihiro Kawakami, Kae Yokoyama, Takaharu Ikeda, Hiroki Tomizawa, Shigeharu Ueki   +4 more
openaire   +2 more sources

Reactive oxygen species are involved in eosinophil extracellular traps release and in airway inflammation in asthma

Journal of Cellular Physiology, 2019
In asthma, there are high levels of inflammatory mediators, reactive oxygen species (ROS), and eosinophil extracellular traps (EETs) formation in airway. Here, we attempted to investigate the ROS involvement in EETs release and airway inflammation in OVA‐
J. Silveira, G. L. Antunes, Daniela Benvenutti Kaiber, Mariana Severo da Costa, E. P. Marques, F. Ferreira, Rodrigo B. Gassen, Ricardo Vaz Breda, Angela T. S. Wyse, P. Pitrez, A. D. da Cunha   +10 more
semanticscholar   +1 more source

EcN-Sj16-Exo ameliorates experimental asthma by inhibiting eosinophil extracellular traps formation via N-WASP upregulation.

European Respiratory Journal
BACKGROUND Eosinophilic inflammation is a feature of allergic asthma, with eosinophil depletion shown to alleviate symptoms. Elevated levels of eosinophil extracellular traps (EETs) in bronchoalveolar lavage fluid (BALF) correlate with asthma severity ...
Xi Sun, Y. Liao, Ji Wu, Yuheng Liu, Dinghao Li, Zifeng Zhu, Yun Huang, Junwei Wu, Peiying Peng, J. Su, Ying He, Mengxi Yanglan, Haiyi Deng, Feiyang Cao, Junhao Xu, Zhongdao Wu, Lifu Wang   +16 more
semanticscholar   +1 more source

Active eosinophilic esophagitis is characterized by epithelial barrier defects and eosinophil extracellular trap formation

Allergy, 2015
Eosinophilic esophagitis (EoE) exhibits esophageal dysfunction owing to an eosinophil-predominant inflammation. Activated eosinophils generate eosinophil extracellular traps (EETs) able to kill bacteria. There is evidence of an impaired barrier function in EoE that might allow pathogens to invade the esophagus.
D. Simon, S. Radonjic-Hösli, A. Straumann, S. Yousefi, H.-U. Simon   +4 more
openaire   +2 more sources

Prognostic Significance of Eosinophil Extracellular Traps in Chronic Rhinosinusitis and Innovative Nanosheets-Based Clearance Therapy.

Clinical and Experimental Allergy
BACKGROUND Chronic rhinosinusitis with nasal polyps (CRSwNP) can be classified into Eosinophilic CRSwNP (ECRSwNP) and non-Eosinophilic CRSwNP (nECRSwNP) based on eosinophilic infiltration in nasal polyps.
Changhui Chen, Hang Li, Yilin Hou, Yihui Wen, Jian Li, Hua Zhong, T. Lu, Zhengqi Li, Lin Sun, Shimin Lai, Yan Yan, Jieying Yan, Zihan Qiu, Nan Zhang, Claus Bachert, Zhaoxu Tu, Weiping Wen, Yi Wei   +17 more
semanticscholar   +1 more source

Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus

Journal of Allergy and Clinical Immunology, 2018
Eosinophils mediate the immune response in different infectious conditions. The release of extracellular DNA traps (ETs) by leukocytes has been described as an innate immune response mechanism that is relevant in many disorders including fungal diseases. Different stimuli induce the release of human eosinophil ETs (EETs).
Valdirene S, Muniz, Juliana C, Silva, Yasmim A V, Braga, Rossana C N, Melo, Shigeharu, Ueki, Masahide, Takeda, Akira, Hebisawa, Koichiro, Asano, Rodrigo T, Figueiredo, Josiane S, Neves   +9 more
openaire   +2 more sources

Autophagy induces eosinophil extracellular traps formation and allergic airway inflammation in a murine asthma model

Journal of Cellular Physiology, 2019
Studies have shown autophagy participation in the immunopathology of inflammatory diseases. However, autophagy role in asthma and in eosinophil extracellular traps (EETs) release is poorly understood.
J. Silveira, G. L. Antunes, Daniela Benvenutti Kaiber, Mariana Severo da Costa, F. Ferreira, E. P. Marques, F. Schmitz, Rodrigo B. Gassen, Ricardo Vaz Breda, Angela T. S. Wyse, R. Stein, P. Pitrez, A. D. da Cunha   +12 more
semanticscholar   +1 more source