Results 71 to 80 of about 23,268 (212)

Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins. [PDF]

, 2021
Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for granule proteins that play important roles in the immune function of granulocytes.
Gigon, Lea, Karaulov, Alexander, Simon, Hans-Uwe, Yousefi, Shida   +3 more
core   +1 more source

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, EarlyView.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies. [PDF]

, 2014
Neuromyelitis optica (NMO) is an autoimmune disease of the CNS that is characterized by inflammatory demyelinating lesions in the spinal cord and optic nerve, potentially leading to paralysis and blindness.
A Bar-Or, A Davies, A Iyer, A Jacob, A Jacob, A Jacob, A Jacob, A McKeon, A Nagaishi, A Rossi, A Uzawa, A Warth, AE Damiano, Alan S. Verkman, AMC Faria, B Banwell, B Bielekova, B Bourre, B Weinstock-Guttman, BA Cree, BC Kieseier, BG Weinshenker, BL Raveendra, BM Greenberg, BM Greenberg, C Costanzi, C Trebst, C Wrzos, CF Lucchinetti, CH Polman, D Ricklin, D Ricklin, D Yuksel, DB Bichuetti, DB Bichuetti, DG Brum, DJ Kimbrough, DK Sato, DM Wingerchuk, DM Wingerchuk, E Gomori, EW Gelfand, F Shimizu, G Pentón-Rol, GG Illei, GS Bedi, H Kita, H Merle, H Wang, H Wen, H Yaguchi, H Zephir, H Zhang, H Zhang, HH Wang, HL Pellkofer, HL Pellkofer, HL Pellkofer, HM Reeves, I Ayzenberg, I Kleiter, I Kleiter, I Nakashima, J Bakker, J Fagius, J Kitley, J Kitley, J Kitley, J Kitley, J Kitley, J Kitley, J Palace, J Ratelade, J Ratelade, J Ratelade, J Ratelade, J Shimizu, JA Cabrera-Gomez, Jeffrey L. Bennett, JH Min, JL Bennett, JM Crane, JM Tillema, JR Faulkner, JS Wu, K Iwata, K Kawabata, K Miyamoto, K Okada, K Rostasy, K Sugita, KR Carson, L Elsone, L Tradtrantip, L Tradtrantip, L Tradtrantip, L Tradtrantip, LA Lewis, M Araki, M Barnett, M Bonnan, M Bonnan, M Botto, M Bradl, M Collin, M De Falco, M Keegan, M Koga, M Matiello, M Matiello, M Pohl, M Reindl, M Ringelstein, M Varrin-Doyer, MA Mealy, MA Sahraian, Marios C. Papadopoulos, MC Papadopoulos, MJ Magraner, N Asavapanumas, N Asavapanumas, N Asgari, N Chihara, N Chihara, N Muls, O Hammer, P Cabre, P Huppke, P Imbach, PF Zipfel, PJ Barnes, PW Phuan, PW Phuan, PW Phuan, R Deschamps, R Reuss, RC Axtell, RE Young, RR Voskuhl, S Izaki, S Jacob, S Jarius, S Jarius, S Jarius, S Jarius, S Jarius, S Jarius, S Jarius, S Kim, S Mader, S Mihai, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Watanabe, S-H Kim, S-H Kim, S-H Kim, S-H Kim, SH Kim, SJ Pittock, SR Hinson, SR Hinson, SR Hinson, SR Kalluri, T Hosokawa, T Kageyama, T Matsuoka, T Matsushita, T Vincent, TE Lotze, TF Tedder, UC Linhares, V Papayannopoulos, VA Lennon, VA Lennon, VT Chu, W Kim, Y Li, Y Warabi, YD Fragoso   +183 more
core   +1 more source

Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation. [PDF]

, 2023
Neutrophils are a specialized subset of white blood cells, which have the ability to store pre-formed mediators in their cytoplasmic granules. Neutrophils are well-known effector cells involved in host protection against pathogens through diverse ...
Fettrelet, Timothée, Gigon, Lea, McLeish, Kenneth R, Miholic, Marta, Simon, Hans-Uwe, Stojkov, Darko, Yousefi, Shida   +6 more
core   +1 more source

Interstitial Lung Disease in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A European Multicenter Study

Arthritis &Rheumatology, EarlyView.
Objective Interstitial lung disease (ILD) can occur in association with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV‐ILD) or as an isolated entity with positive ANCA (ANCA‐ILD). However, data on the epidemiology and outcomes of these conditions remain limited.
Aglaia Chalkia, Marusa Kotnik, Timothy J. Sadler, Spyridon Katechis, Rachel Jones, Ajay Kamath, Aladdin J. Mohammad, Sara Monti, Chetan Mukhtyar, Viral Nanda, Ioannis Petrakis, Dimitrios Petras, Ashnish Sinha, Pasupathy Sivasothy, Rona Smith, Kostas Stylianou, Dimitrios Vassilopoulos, Judith Babar, David Jayne   +18 more
wiley   +1 more source

Extracellular Traps: A Novel Therapeutic Target for Severe Asthma

Journal of Asthma and Allergy, 2022
Youngwoo Choi,1 Quoc Quang Luu,1,2 Hae-Sim Park1,2 1Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea; 2Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, KoreaCorrespondence: Hae ...
Choi Y, Luu QQ, Park HS
doaj  

The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease

Frontiers in Medicine, 2018
Bullous pemphigoid (BP) is an autoimmune blistering disease which carries a significant mortality and morbidity. While historically BP has been characterized as an IgG driven disease mediated by anti-BP180 and BP230 IgG autoantibodies, developments in ...
Kyle T. Amber, Manuel Valdebran, Khalaf Kridin, Sergei A. Grando, Sergei A. Grando   +4 more
doaj   +1 more source

Eosinophil extracellular trap cell death–derived DNA traps: Their presence in secretions and functional attributes [PDF]

Journal of Allergy and Clinical Immunology, 2016
Activated human eosinophils, as well as neutrophils, can release extracellular chromatin to form DNA traps through cytolytic extracellular trap cell death (ETosis). Although formations of neutrophil DNA traps are recognized in patients with various inflammatory conditions, neither the presence of ETosis-derived eosinophil DNA traps in human allergic ...
Shigeharu, Ueki, Yasunori, Konno, Masahide, Takeda, Yuki, Moritoki, Makoto, Hirokawa, Yoshinori, Matsuwaki, Kohei, Honda, Nobuo, Ohta, Shiori, Yamamoto, Yuri, Takagi, Atsushi, Wada, Peter F, Weller   +11 more
openaire   +2 more sources

Multi‐omic profiling reveals immune cell priming signature linked to lupus prognosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is a multi‐organ disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source