Results 141 to 150 of about 99,139 (308)
Εosinophilic Chronic Obstructive Pulmonary Disease. What Do We Know So Far?
Pulmonary TherapyThe latest advances in asthma treatment have highlighted the significance of eosinophilia and the possible role of some pro-eosinophilic mediators, like interleukins (IL) IL-5, IL-4/IL-13, and IL-33 in the disease’s pathogenesis.
Konstantinos Bartziokas +5 more
doaj +1 more source
Allergy, EarlyView.This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake +8 more
wiley +1 more source
Allergy, EarlyView.This study comprehensively characterizes non‐specific esophagitis and elucidates eosinophil‐independent fibrosis mechanisms. NSE appears to be a distinct fibrotic phenotype of the esophagus, without any considerable overlap with GERD and other chronic inflammatory disorders such as EoE or lymphocytic esophagitis.
Marc Pfefferle +16 more
wiley +1 more source
Eosinophilia in the tropics. Not always tropical eosinophilia
Mediterranean Journal of Hematology and Infectious Diseases, 2014 Hypereosinophilia is a commonly encountered problem in tropical settings. Higher rates of parasitic infestations contribute to its prevalence in these areas.
Arjun Datt Law
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Allergy, EarlyView.Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton +19 more
wiley +1 more source
MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation
Allergy, EarlyView.In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata +6 more
wiley +1 more source
Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma
Allergy, EarlyView.EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler +22 more
wiley +1 more source
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) - A Case Report
SRM Journal of Research in Dental Sciences, 2012 Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign self-limiting oral ulcerative lesion which mimics malignant lesion clinically.
G Suresh Babu +2 more
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