Results 1 to 10 of about 280,047 (395)
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status [PDF]
Nature Communications, 2019 Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study
Paul Lyons +80 more
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Endotyping of nasal polyps in a multiracial Asian population [PDF]
Rhinology Online, 2022 Background: Chronic rhinosinusitis is a heterogenous disease with variation in the endotypes of nasal polyps, with type 2 inflammation being more prevalent in Caucasian populations whereas Chinese populations are more heterogenous. We aim to describe the
Shuhui Xu +4 more
doaj +1 more source
Cells, 2021 Eosinophils are implicated in the pathophysiology of a spectrum of eosinophil-associated diseases, including gastrointestinal eosinophilic diseases (EGIDs).
Joanne C. Masterson +4 more
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Annals of the Rheumatic Diseases, 2022 Objective To develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA). Methods Patients with vasculitis or comparator diseases were recruited into an international cohort.
P. Grayson +10 more
semanticscholar +1 more source
Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.
New England Journal of Medicine, 2022 BACKGROUND Dupilumab, a fully human monoclonal antibody, blocks interleukin-4 and interleukin-13 signaling, which have key roles in eosinophilic esophagitis.
E. Dellon +29 more
semanticscholar +1 more source
Communications Biology, 2023 The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-regulated immune responses operational in eosinophilic esophagitis (EoE).
Chandra Sekhar Yadavalli +6 more
doaj +1 more source
Eosinophils in eosinophilic pneumonia [PDF]
European Respiratory Journal, 1996 Idiopathic eosinophilic pneumonia (IEP) is an uncom-mon disease of unknown aetiology characterized by theaccumulation of eosinophils in the lung, variable bloodeosinophilia and peripheral opacities on the chest radio-gram. The response to steroid treatment is dramatic butrelapses are frequent, requiring the use of long-termsteroid treatment [1 ...
ALBERA, Carlo, P. GHIO
openaire +2 more sources
Characterisation of Eosinophilic Bronchiectasis: A European Multicohort Study.
American Journal of Respiratory and Critical Care Medicine, 2022 RATIONALE Bronchiectasis is classically considered a neutrophilic disorder but eosinophilic subtypes have recently been described. OBJECTIVES To use multiple datasets available through the EMBARC consortium to characterise eosinophilic bronchiectasis ...
A. Shoemark +18 more
semanticscholar +1 more source
Eosinophils and eosinophilic immune dysfunction in health and disease
European Respiratory Review, 2022 The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood ...
D. Jackson, P. Akuthota, F. Roufosse
semanticscholar +1 more source
New England Journal of Medicine, 2021 Eosinophilic esophagitis (also known as EoE) is a disease characterized by the presence of a large number of a special type of white blood cell, the eosinophil, that can cause inflammation in the esophagus.
G. Furuta, D. Katzka
semanticscholar +1 more source