Results 1 to 10 of about 242,070 (197)

Endotyping of nasal polyps in a multiracial Asian population [PDF]

Rhinology Online, 2022
Background: Chronic rhinosinusitis is a heterogenous disease with variation in the endotypes of nasal polyps, with type 2 inflammation being more prevalent in Caucasian populations whereas Chinese populations are more heterogenous. We aim to describe the
Shuhui Xu, M. Vallei, Jacqueline Hwang Siok Gek, Charn Tze Choong, Neville Wei Yang Teo   +4 more
doaj   +1 more source

Heterogeneity of Intestinal Tissue Eosinophils: Potential Considerations for Next-Generation Eosinophil-Targeting Strategies

Cells, 2021
Eosinophils are implicated in the pathophysiology of a spectrum of eosinophil-associated diseases, including gastrointestinal eosinophilic diseases (EGIDs).
Joanne C. Masterson, Calies Menard-Katcher, Leigha D. Larsen, Glenn T. Furuta, Lisa A. Spencer   +4 more
doaj   +1 more source

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis

Annals of the Rheumatic Diseases, 2022
Objective To develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA). Methods Patients with vasculitis or comparator diseases were recruited into an international cohort.
P. Grayson, C. Ponte, R. Suppiah, J. Robson, A. Craven, A. Judge, S. Khalid, A. Hutchings, R. Luqmani, R. Watts, P. Merkel   +10 more
semanticscholar   +1 more source

Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.

New England Journal of Medicine, 2022
BACKGROUND Dupilumab, a fully human monoclonal antibody, blocks interleukin-4 and interleukin-13 signaling, which have key roles in eosinophilic esophagitis.
E. Dellon, M. Rothenberg, M. Collins, I. Hirano, M. Chehade, A. Bredenoord, A. Lucendo, J. Spergel, S. Aceves, Xian Sun, M. Kosloski, Mohamed A. Kamal, J. Hamilton, B. Beazley, E. McCann, Kiran M. Patel, L. Mannent, E. Laws, B. Akinlade, N. Amin, W. Lim, M. Wipperman, M. Ruddy, N. Patel, David R. Weinreich, G. Yancopoulos, B. Shumel, J. Maloney, A. Giannelou, A. Shabbir   +29 more
semanticscholar   +1 more source

Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis

Communications Biology, 2023
The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-regulated immune responses operational in eosinophilic esophagitis (EoE).
Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Sandeep Kumar, Hemanth Kumar Kandikattu, Lokanatha Oruganti, Chandra Sekhar Kathera, Anil Mishra   +6 more
doaj   +1 more source

Characterisation of Eosinophilic Bronchiectasis: A European Multicohort Study.

American Journal of Respiratory and Critical Care Medicine, 2022
RATIONALE Bronchiectasis is classically considered a neutrophilic disorder but eosinophilic subtypes have recently been described. OBJECTIVES To use multiple datasets available through the EMBARC consortium to characterise eosinophilic bronchiectasis ...
A. Shoemark, M. Shteinberg, A. De Soyza, C. Haworth, H. Richardson, Yong-hua Gao, L. Perea, A. Dicker, P. Goeminne, E. Cant, E. Polverino, J. Altenburg, Holly R. Keir, M. Loebinger, F. Blasi, T. Welte, O. Sibila, S. Aliberti, J. Chalmers   +18 more
semanticscholar   +1 more source

Eosinophilic Esophagitis.

New England Journal of Medicine, 2021
Eosinophilic esophagitis (also known as EoE) is a disease characterized by the presence of a large number of a special type of white blood cell, the eosinophil, that can cause inflammation in the esophagus.
G. Furuta, D. Katzka
semanticscholar   +1 more source

Eosinophils and eosinophilic immune dysfunction in health and disease

European Respiratory Review, 2022
The functions ascribed to eosinophils have classically been limited to host defence against certain parasitic infections and potentially deleterious effects in the setting of specific diseases that are associated with elevated eosinophil counts in blood ...
D. Jackson, P. Akuthota, F. Roufosse
semanticscholar   +1 more source

Eosinophilic Esophagitis: A Review.

Journal of the American Medical Association (JAMA), 2021
Importance Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease of the esophagus that affects an estimated 34.4/100 000 people in Europe and North America.
A. Muir, G. Falk
semanticscholar   +1 more source

Comparison of the respiratory bacterial microbiome in cats with feline asthma and chronic bronchitis

Frontiers in Veterinary Science, 2023
ObjectivesWhile feline chronic bronchitis (CB) is known as neutrophilic bronchial inflammation (NI), feline asthma (FA) is defined as an eosinophilic airway inflammation (EI).
Melanie Werner, Melanie Werner, Jasmin Weeger, Lina Hörner-Schmid, Karin Weber, Jelena Palić, Jonathan Shih, Jan S. Suchodolski, Rachel Pilla, Bianka Schulz   +9 more
doaj   +1 more source