Results 101 to 110 of about 116,850 (267)

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Role of Vasoactive Intestinal Peptide in Promoting the Pathogenesis of Eosinophilic Esophagitis (EoE)

Cellular and Molecular Gastroenterology and Hepatology, 2018
Alok K. Verma, Murli Manohar, Sathisha Upparahalli Venkateshaiah, Uwe Blecker, Margaret H. Collins, Anil Mishra   +5 more
doaj   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Unraveling ovarian histology: The key morphological aspects that spur the development of the Fossa ovarii in equine

The Anatomical Record, EarlyView.
Abstract The equine ovary exhibits unique structural and developmental features that distinguish it from those of other domestic species, including the presence of an ovulation fossa and an inversion of cortical and medullary layers. This study aimed to investigate the morphostructural development of the equine fetal ovary, with particular emphasis on ...
Laura Ver Goltz, Silvio Pires Gomes, Bruno Cesar Schimming, Fabio Cesar Magioli Abdala, Maria Angélica Miglino, Tais Harumi de Castro Sasahara   +5 more
wiley   +1 more source

Burden of hypereosinophilic syndromes in the United States: Patients’ perspective

Journal of Allergy and Clinical Immunology: Global
Background: Hypereosinophilic syndromes (HES) are rare hematologic disorders characterized by hypereosinophilia and eosinophil-driven organ damage/dysfunction. The HES diagnostic and treatment journey is poorly understood.
Jared Silver, MD, PhD, Anna Kovalszki, MD, Mary Jo Strobel, Dan Gratie, PharmD, MS, Amy G. Edgecomb, PharmD, MPH, Cara Schmitt, MS, Waseem Ahmed, BSc, MBA, Arijita Deb, PhD   +7 more
doaj   +1 more source

Hepatic morphology and serum biochemical profile according to dry and rainy seasons in Pygocentrus nattereri (Characiformes: Serrasalmidae)

The Anatomical Record, EarlyView.
Abstract This study investigated the physiological and morphological adaptations of the liver of the carnivorous fish Pygocentrus nattereri (piranha) in response to seasonal variations (dry and rainy seasons) in the Brazilian Pantanal. The objective was to describe how the liver, a central organ in metabolic regulation, responds to environmental ...
Maria Eduarda Corona Garcia, Sandriely F. Marcondes, Mayara S. Siqueira, Taynara R. F. Leão, Robson A. Rodrigues, Karine N. N. Farias, André L. N. Silva, Karin Virgínia Kuibida, Lilian Franco‐Belussi, Carlos E. Fernandes   +9 more
wiley   +1 more source

Feline gastrointestinal eosinophilic sclerosing fibroplasia associated with Candida albicans

Veterinary Medicine and Science
Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a rare and poorly understood disease characterised by the infiltration of eosinophils and the development of fibrous tissue within the gastrointestinal tract of cats.
Angel Almendros, Antonio Giuliano, May Tse, Vanessa Rosemary Barrs   +3 more
doaj   +1 more source

Developmental morphology of claspers and clasper‐glands during maturation in Potamotrygon wallacei (Chondrichthyes: Potamotrygoninae)

The Anatomical Record, EarlyView.
Abstract The claspers are the copulatory organs in male elasmobranchs, responsible for directing the semen into the female cloaca (C). However, the microscopic morphology of the claspers remains poorly understood. This study describes the morphology of the claspers and clasper glands (CGs) of cururu stingray (Potamotrygon wallacei) at different ...
Matheus Samuel Cunha Braga, Grazyelle Sebrenski da Silva, Maria Inês Braga de Oliveira, Jaydione Luiz Marcon, Ruben Dario Morales Gamba   +4 more
wiley   +1 more source

Assessment of MUcociLiary Transport timE in CRSwNP Patients in Treatment With Dupilumab: AMULET Study

International Forum of Allergy &Rhinology, EarlyView.
Alessia Giorli, Fabio Ferretti, Antonio Romano, Marco Casiraghi, Mariella Scarano, Paolo Farneti, Giacomo Sollini, Marco Mandalà, Ernesto Pasquini, Cesare Biagini   +9 more
wiley   +1 more source

Male reproductive system in stenopodidean shrimps: Unveiling basal reproductive traits in shrimp‐like Pleocyemata (Stenopodidae and Spongicolidae)

The Anatomical Record, EarlyView.
Abstract Stenopodidea represents one of the basal lineages within Pleocyemata, yet the male reproductive system (MRS) of this group remains poorly understood, with limited information available regarding its morphology and function. This study provides the first detailed description of the MRS in four stenopodidean shrimp species from two families ...
Caio Santos Nogueira, Lucas Rezende Penido Paschoal, Fernando José Zara   +2 more
wiley   +1 more source