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Targeting Eosinophils in Eosinophilic Granulomatosis with Polyangiitis

New England Journal of Medicine, 2017
Eosinophilic granulomatosis with polyangiitis, first described in the early 1950s by Dr. Jacob Churg and Dr. Lotte Strauss (hence the original name, the Churg–Strauss syndrome), is a rare condition that can affect many organ systems, most commonly the lung, with the majority of patients presenting with asthma symptoms, occasionally complicated by the ...
Djukanović, Ratko, O'Byrne, Paul
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Eosinophils

2014
In 1846, T. Wharton-Jones described a coarsely granular stage in the development of granulocytic cells in animal and human blood. Shortly thereafter, Max Schultze redefined the coarsely granular cells as a type distinct from finely granular cells, rather than just a developmental stage.
Susanne Radonjic-Hösli, Hans-Uwe Simon
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Eosinophilic Cationic Protein in Chronic Eosinophilic Pneumonia and Eosinophilic Granuloma

Chest, 1994
We measured eosinophilic cationic protein (ECP) concentrations in the circulation and bronchoalveolar lavage (BAL) fluids from patients with chronic eosinophilic pneumonia, patients with eosinophilic granuloma, and normal control subjects. Significantly increased ECP concentrations were found in the circulation of patients with chronic eosinophilic ...
N, Shijubo   +4 more
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Eosinophilic Esophagitis

Annals of Internal Medicine, 2003
Eosinophilic esophagitis is a new disease commonly confused with gastroesophageal reflux disease. Because of different treatments, recognition of eosinophilic esophagitis is important.Recent work further characterizes the allergic response, demonstrating a population of eosinophils different from gut and blood that specifically homes to the esophagus ...
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Eosinophilic cellulitis and eosinophilic pustular folliculitis

Journal of the American Academy of Dermatology, 1989
This report describes a patient with a drug reaction and histologic changes of both eosinophilic cellulitis and eosinophilic pustular folliculitis. We propose that some cases of eosinophilic pustular folliculitis, like eosinophilic cellulitis, may occur as a result of a hypersensitivity phenomenon.
J M, Andreano   +4 more
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Eosinophilic esophagitis: A subset of eosinophilic gastroenteritis

Current Gastroenterology Reports, 1999
Eosinophilic gastroenteritis (EG) was first described over 50 years ago. Despite its long history, it remains an ill-defined and poorly understood entity. EG can present in a number of ways, none of which are exclusive to the disorder. EG has features of allergy and immune dysregulation but does not clearly fit into the category of allergic or immune ...
C A, Liacouras, J E, Markowitz
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Heterogeneity of Eosinophils in Chronic Eosinophilic Pneumonia

International Archives of Allergy and Immunology, 2009
It has previously been shown that patients with chronic eosinophilic pneumonia can be divided into 2 groups according to the chemotactic response of their eosinophils to 5 different eosinophil chemotactic factors (ECFs) and laboratory findings. In contrast, eosinophils obtained by bronchoalveolar lavage from both groups responded to all 5 ECFs.
N, Saita   +6 more
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Activated Eosinophils in Familial Eosinophilic Gastroenteritis

Gastroenterology, 1985
Two siblings with eosinophilic gastroenteritis who presented with severe iron deficiency anemia and hypoalbuminemia associated with varying degrees of mucosal damage are described. Using a monoclonal antibody to the secreted form of eosinophil cationic protein, we demonstrated activated degranulating eosinophils in the gastrointestinal mucosa that ...
A, Keshavarzian   +6 more
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Pseudoeosinophilia, eosinophilic endocarditis and eosinophilic leukemia

The American Journal of Medicine, 1972
Abstract Three patients with eosinophilia of diverse etiology are described. All three had cardiopulmonary symptoms and hepatosplenomegaly in addition to the eosinophilia. One patient was found to have reactive eosinophilia and lesions in the heart typical of Loeffler's endocarditis.
L T, Yam   +3 more
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Eosinophilic Pancreatitis and Increased Eosinophils in the Pancreas

The American Journal of Surgical Pathology, 2003
Prominent eosinophilic infiltrates are an unusual finding in the pancreas. Eosinophilic pancreatitis is one rare etiology of pancreatic eosinophilia, but other described causes of eosinophilic infiltrates have also included pancreatic allograft rejection, pancreatic pseudocyst, lymphoplasmacytic sclerosing pancreatitis (LPSP), inflammatory ...
Susan C, Abraham   +7 more
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