Results 131 to 140 of about 106,180 (310)

Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis.

Gastroenterology, 2019
BACKGROUND & AIMS Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease with no approved treatment in the United States. Dupilumab, a VelocImmune-derived human monoclonal antibody against the interleukin 4 (IL4) receptor, inhibits ...
I. Hirano, E. Dellon, J. Hamilton, M. Collins, K. Peterson, M. Chehade, A. Schoepfer, E. Safroneeva, M. Rothenberg, G. Falk, Y. Assouline-Dayan, Q. Zhao, Zhen Chen, B. Swanson, G. Pirozzi, L. Mannent, N. Graham, B. Akinlade, N. Stahl, G. Yancopoulos, A. Radin   +20 more
semanticscholar   +1 more source

IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy

Allergy, EarlyView.
We used patient samples and a murine model to understand the contribution of Bregs to EoE immunopathology. We find that Breg‐derived IL‐10 is important for controlling EoE, but that Breg expansion and function are impaired in this condition. We identify IFNγ as a key negative regulator of Breg function in mice and patients with EoE. Bregs, regulatory B
Rachel L. Clement, Julie Dilollo, Eric M. Rodríguez‐López, Cleandre M. Guerrier, David A. Hill   +4 more
wiley   +1 more source

Mepolizumab Effectiveness in Severe Asthma With/Without Chronic Rhinosinusitis With Nasal Polyps: Real‐World Pooled Analysis

Allergy, EarlyView.
MEPOLYP was a pooled analysis of 1037 patients with SAEP[±]CRSwNP. Mepolizumab was associated with a reduction in CSEs, OCS use, and BEC, and improved lung function and ACT score. Over 47% of patients fulfilled ≥ 3 clinical remission criteria. When compared, there was a 30.0% incremental benefit of mepolizumab in reducing CSEs for patients with SAEP ...
Florence Schleich, Stelios Loukides, Rekha Chaudhuri, Joerg D. Leuppi, Enrico Heffler, Cristian Domingo, Claudio Micheletto, Thomas Paulsson, Nina Gaw, Konstantina Kallinikou, Carla Vossen, Florent Guelfucci, Jyothi Menon, Armel Ngami, Ines Palomares   +14 more
wiley   +1 more source

Esofagite eosinofílica: uma patologia emergente em pediatría.

Acta Médica Portuguesa, 2009
Eosinophilic Esophagitis has been increasingly diagnosed and results from a chronic esophagic inflammation with eosinophilic infiltrate.Evaluation of the diagnosed paediatric cases in our centre between 2004 and 2008 and revision of current literature on
Hugo Braga-Tavares, Andreia Teles, Rosete Nogueira, Fernando Cardoso Rodrigues, Cristina Costa   +4 more
doaj   +1 more source

Nonerosive reflux disease :comparative analysis of symptoms severity, endoscopic and 24-hours ph-impedance [PDF]

, 2015
Background : Non--‐erosive reflux disease (NERD) has emerged as a real entity in the spectrum of gastroesophageal reflux disease (GERD) and may, indeed, represent the most common manifestation of reflux disease.
Nordin, Noorlina
core  

Serum MicroRNA-21 as a Biomarker for Allergic Inflammatory Disease in Children [PDF]

, 2015
MicroRNAs (miRs) have emerged as useful biomarkers for different disease states, including allergic inflammatory diseases such as asthma and eosinophilic esophagitis (EoE). Serum miRs are a possible non-invasive method for diagnosis of such diseases.
Dent, Alexander L., Gupta, Sandeep K., Kaplan, Mark H., Sawant, Deepali V., Sawyers, Cindy, Tepper, Robert S., Wright, Zachary, Yao, Weiguo   +7 more
core   +1 more source

Systematic Review: Variability in Definitions of Fibrostenosis in Eosinophilic Oesophagitis

Alimentary Pharmacology &Therapeutics, EarlyView.
Significant variability exists in definitions and diagnostic methods of detection regarding fibrostenosis in eosinophilic oesophagitis. Lack of consensus poses a barrier in clinical care and research. ABSTRACT Background Fibrostenosis is a serious complication of eosinophilic oesophagitis, but there is a lack of consensus regarding its definition and ...
Claire A. Beveridge, Natalie Farha, Christina Hermanns, Chiara Maruggi, Katherine Falloon, Shivani Thanawala, Mary Pat Harnegie, J. Mark Brown, Andrei I. Ivanov, Evan S. Dellon, Gary W. Falk, Christopher Ma, Nirmala Gonsalves, Anthony Lembo, Amanda B. Muir, Scott Gabbard, Glenn T. Furuta, Florian Rieder   +17 more
wiley   +1 more source

Assessment of Fractionated Exhaled Nitric Oxide as a Biomarker for the Treatment of Eosinophilic Esophagitis [PDF]

, 2012
Diagnosis of eosinophilic esophagitis (EoE) and determination of response to therapy is based on histological assessment of the esophagus, which requires upper endoscopy.
Bonis, Peter A., Chan, Walter Wai-Yip, Lee, Erika M., Leung, John, Ngo, Peter, Nguyen-Traxler, Ann, Weinstein, Barbara J., Weinstock, Joel V., Yip, Jason S.   +8 more
core   +1 more source

Combined Lyon and Milan Scores Predict Gerd Management Outcome Better Than Either Score Alone or Their Individual Components

Alimentary Pharmacology &Therapeutics, EarlyView.
The Lyon and Milan scores outperformed AET and DeMeester score in predicting outcomes in GERD patients. When concordant, they provide optimal predictive accuracy, guiding escalation of therapy. ABSTRACT Background Confidence in gastro‐oesophageal reflux disease (GERD) diagnosis is crucial to improve outcomes from escalation of treatment. The Lyon score
Stefano Siboni, Marco Sozzi, Pierfrancesco Visaggi, Sara Boveri, Benjamin D. Rogers, Nicola De Bortoli, Anthony Hobson, Brian E. Louie, Yeong Yeh Lee, Salvatore Tolone, Elisa Marabotto, Jordan Haworth, Megan L. Ivy, Lorenzo Cusmai, Edoardo Campioli, Dimitrios Theodorou, Tania Triantafyllou, Andrea Pasta, Francesco Calabrese, Vincent Tee, Daniele Bernardi, Carlo Galdino Riva, Roberta De Maron, Enrique Coss‐Adame, Amit Patel, Emanuele Asti, Edoardo Savarino, C. Prakash Gyawali   +27 more
wiley   +1 more source

Mediastinal abscess, an unusual way of presentation of eosinophilic esophagitis

Allergy, Asthma & Clinical Immunology, 2019
Eosinophilic esophagitis (EoE) is one of the most prevalent esophageal diseases and the leading cause of dysphagia and food impaction in children and young adults.
Paul Gisasola, Ainara Iriarte, Martha Rosa Larez, Laura Casanova, Luis Bujanda   +4 more
doaj   +1 more source