Results 101 to 110 of about 21,150 (239)

Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro‐Inflammatory Responses and IgE Production

Allergy, EarlyView.
Soy lecithin and DATEM, the two commonly used food emulsifiers introduced into many foods including peanut butter and puffed bread, in the 2000s, impair intestinal epithelial barrier integrity in human gut‐on‐a‐chip and induced pluripotent stem cell colon organoid models.
Duygu Yazici, Yuka Hayashi, Yagiz Pat, Jennifer Hotie, Mehmet Ali Balci, Sena Ardicli, Juan Felipe Lopez, Ozge Ardicli, Bingjie Zhao, Angel Maldonado, Can Zeyneloglu, Kenji Matsumoto, Manru Li, Beate Rückhert, Lihong Chang, Ismail Ogulur, Vahap Eldem, Raja Dhir, Mubeccel Akdis, Kari Nadeau, Oscar Palomares, Hideaki Morita, Cezmi A. Akdis   +22 more
wiley   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean C. Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Safety and Clinical Outcomes of High‐ Versus Low‐Dose Oral Peanut Immunotherapy in Polish Children With Peanut Allergy

Acta Paediatrica, EarlyView.
ABSTRACT Aim To compare safety and clinical outcomes of two different oral immunotherapy (OIT) maintenance doses (150 mg vs. 300 mg) of peanut protein in children with peanut allergy. Methods This prospective study enrolled 44 children aged 4–17 years with confirmed peanut allergy.
Klementyna Łyżwa, Magdalena Chojnowska‐Wójtowicz, Wioletta Zagórska, Marek Kulus, Katarzyna Grzela   +4 more
wiley   +1 more source

Impact of Upper Gastrointestinal Involvement on Clinical Outcomes in Paediatric Inflammatory Bowel Disease

Acta Paediatrica, EarlyView.
ABSTRACT Aim The aim of this study was to assess the clinical implications of upper gastrointestinal (UGI) involvement in paediatric inflammatory bowel disease (IBD). Methods This retrospective cohort study included children diagnosed with IBD between 2010 and 2023, who underwent a UGI endoscopic evaluation at diagnosis and were followed for at least ...
Ofek Aloni, Adi Anafy, Hadar Moran‐Lev, Achiya Amir, Alma Ziv, Reut Doyev, Tut Galai, Shlomi Cohen, Anat Yerushalmy‐Feler   +8 more
wiley   +1 more source

Eosinophilic Oesophagitis Beyond the Oesophagus: High Prevalence of Chronic Rhinosinusitis‐Type Symptoms and Their Impact on Symptom Severity in Swiss EoE Cohort Study Patients

Alimentary Pharmacology &Therapeutics, EarlyView.
Among 211 prospectively followed Swiss patients with eosinophilic oesophagitis, chronic rhinosinusitis was two‐ to three‐fold more common than in the general population. It was associated with greater oesophageal symptom severity and, in a quarter of cases, was experienced by patients as more debilitating than the underlying oesophageal disease ...
Gebhardt Aidan, Kreienbühl Andrea, Greuter Thomas, Schlag Christoph, Nennstiel Simon, Saner Catherine, Rossel Jean‐Benoit, Mauthe Tina, M. Meerwein Christian, Schoepfer Alain, B. Soyka Michael, Straumann Alex, Biedermann Luc, on behalf of the Swiss EoE Cohort Study Group, Patrick Aepli, Luc Biedermann, Ruggero Biral, Carine Blanchard, Simon Buetikofer, Emanuel Burri, Joachim Diebold, Carolien Dietrich, Annett Franke, Michèle Gwerder, Thomas Greuter, Chantal Hasler, Wolfram Jochum, Tanay Kaymak, Andrea Kreienbühl, Katline Metzger‐Peter, Fritz Murray, Simon Nennstiel, Peter Netzer, Jan Hendrik Niess, Gabrielle Reichhart, Cristiana Quattropani, Elodie Ristorcelli, Jean‐Benoit Rossel, Ekaterina Safroneeva, Catherine Saner, Alain Schoepfer, Philip Schreiner, Christine Sempoux, Dagmar Simon, Hans‐Uwe Simon, Alex Straumann, Sven Trelle, Achim Weber, Niels Willi, Elina Wuethrich, Marcel Zwahlen, Michael Scharl, Marcin Wawrzyniak   +52 more
wiley   +1 more source

Current and Novel Therapies for Eosinophilic Gastrointestinal Diseases. [PDF]

Int J Mol Sci, 2023
Marasco G, Visaggi P, Vassallo M, Fiocca M, Cremon C, Barbaro MR, De Bortoli N, Bellini M, Stanghellini V, Savarino EV, Barbara G.   +10 more
europepmc   +1 more source

The benefits of multidisciplinary collaboration in the successful management of two complex feline cases

Australian Veterinary Journal, EarlyView.
Despite a frequent misconception that behavioural concerns are diagnoses of exclusion, medical conditions and behavioural disorders are frequently inter‐related. In human medicine, the ‘multidisciplinary team’ approach (MDTA) is considered the most efficacious way of managing patients with complex and chronic health conditions.
BE Bollaert, JM Ley, HE Zulch
wiley   +1 more source

Sensory Processing Difficulties in Children With Eosinophilic Esophagitis

Brain and Behavior
Background Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease associated with dysphagia, food impaction, feeding difficulties, vomiting, and failure to thrive in children.
Muserrefe Nur Keles, Hacer Ilbilge Ertoy Karagol, Ramazan Yildiz, Odul Egritas Gurkan, Sinan Sari, Bulent Elbasan, Buket Dalgic, Arzu Bakirtas, Gazi University Pediatric Eosinophilic Gastrointestinal Diseases Working Group   +8 more
doaj   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries

Clinical &Experimental Allergy, EarlyView.
There is a tight intersection between asthma, deprivation, ethnicity, multimorbidity and poor clinical outcomes. An integrated, holistic and culturally tailored approach is needed to improve clinical outcomes amongst ethnic minority groups with asthma and multimorbidity. ABSTRACT Asthma is one of the commonest noncommunicable diseases worldwide.
Mamidipudi Thirumala Krishna, Saibal Moitra, Anna Freeman, Ben Ainsworth, Rebecca Knibb, Ramesh Kurukulaaratchy, Adel H. Mansur   +6 more
wiley   +1 more source