Results 31 to 40 of about 14,408 (215)

Genomic insights into pediatric intestinal inflammatory and eosinophilic disorders using single-cell RNA-sequencing

Frontiers in Immunology
IntroductionChronic inflammation of the gastrointestinal tissues underlies gastrointestinal inflammatory disorders, leading to tissue damage and a constellation of painful and debilitating symptoms.
Marissa R. Keever-Keigher, Lisa Harvey, Veronica Williams, Carrie A. Vyhlidal, Atif A. Ahmed, Jeffery J. Johnston, Daniel A. Louiselle, Elin Grundberg, Elin Grundberg, Tomi Pastinen, Tomi Pastinen, Craig A. Friesen, Craig A. Friesen, Rachel Chevalier, Rachel Chevalier, Craig Smail, Craig Smail, Valentina Shakhnovich, Valentina Shakhnovich, Valentina Shakhnovich   +19 more
doaj   +1 more source

Successful use of montelukast in eosinophilic gastroenteritis: a case report and a literature review

BMC Gastroenterology, 2021
Background Eosinophilic gastrointestinal disorders, also known as eosinophilic gastroenteritis, are rare inflammatory conditions characterized by eosinophilic infiltration of different parts of the gastrointestinal tract, along with peripheral ...
Emran A. El-Alali, Ibrahim M. Abukhiran, Tarik Z. Alhmoud   +2 more
doaj   +1 more source

A Rare Case of Eosinophilic Ileitis and the Role of Motorized Spiral Enteroscopy in Its Diagnosis

GE: Portuguese Journal of Gastroenterology, 2022
Introduction: Eosinophilic gastrointestinal disorders are rare idiopathic conditions characterized by eosinophilic infiltration of any area of the gastrointestinal tract.
Isabel Tarrio, Marta Moreira, Tarcísio Araújo, Emília Guerreiro, Carmélia Rodrigues, Luís Lopes   +5 more
doaj   +1 more source

Eosinophil infiltration in the upper gastrointestinal tract of patients with bronchial asthma

Allergology International, 2016
Background: Eosinophilic esophagitis (EoE) is related to allergic diseases such as bronchial asthma (BA), atopic dermatitis, and allergic rhinitis. The aim of this study was to examine the eosinophil infiltration in the upper gastrointestinal (GI) tract ...
Hiroyuki Imaeda, Minoru Yamaoka, Hideki Ohgo, Kazuaki Yoneno, Takehito Kobayashi, Toru Noguchi, Yoshitaka Uchida, Tomoyuki Soma, Hidekazu Kayano, Minoru Kanazawa, Hidetomo Nakamoto, Makoto Nagata   +11 more
doaj   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Unusual presentation of eosinophilic enteritis as multiple strictures of small intestine

Clinics and Practice, 2012
Eosinophilic enteritis is a rare disease of unknown etiology. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract depending upon the predominant layer involved ...
Sunil V. Jagtap, Dhiraj B. Nikumbh, Ashok Y. Kshirsagar, Neha Ahuja   +3 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Eosinophilic Digestive Diseases: Eosinophilic Esophagitis, Gastroenteritis, and Colitis

Journal of the Formosan Medical Association, 2009
Eosinophilic digestive diseases (EDD) are relatively rare disorders associated with increased gastrointestinal eosinophilic infiltrates without any underlying primary etiology.
Allison Shifflet, Faripour Forouhar, George Y. Wu   +2 more
doaj   +1 more source