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Biologic Therapies in Severe Asthma and Eosinophilic Granulomatosis with Polyangiitis: Targeted Therapy and Personalized Care. [PDF]
Kim SH.
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Eosinophilic Granulomatosis with Polyangiitis (EGPA) without History of Asthma [PDF]
Aronin, Ryan G., Sun, Frank
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Eosinophilic granulomatosis with polyangiitis
Medicina Clínica (English Edition), 2023Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis characterized by the presence of asthma associated with eosinophilia, eosinophilic infiltration of different organs, and vasculitis of small and medium-sized vessels. Although classified as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, it occurs in less ...
Yann Nguyen, Loïc Guillevin
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Annals of the Rheumatic Diseases, 2023
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is often associated with glucocorticoid-dependent asthma and/or ear, nose and throat (ENT) manifestations.
Berengere Molina +33 more
semanticscholar +1 more source
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is often associated with glucocorticoid-dependent asthma and/or ear, nose and throat (ENT) manifestations.
Berengere Molina +33 more
semanticscholar +1 more source
Targeting Eosinophils in Eosinophilic Granulomatosis with Polyangiitis
New England Journal of Medicine, 2017Eosinophilic granulomatosis with polyangiitis, first described in the early 1950s by Dr. Jacob Churg and Dr. Lotte Strauss (hence the original name, the Churg–Strauss syndrome), is a rare condition that can affect many organ systems, most commonly the lung, with the majority of patients presenting with asthma symptoms, occasionally complicated by the ...
Djukanović, Ratko, O'Byrne, Paul
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Biologics for eosinophilic granulomatosis with polyangiitis
Current Opinion in Allergy & Clinical Immunology, 2022Purpose of review The link between severe asthma and eosinophilic granulomatosis with polyangiitis (EGPA) in terms of pathophysiological background, clinical manifestations and disease evolution has leaded to investigate the relevance of anti T2 monoclonal antibodies licensed for severe asthma patients as a treatment option for
Caminati, Marco +3 more
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The Lancet Rheumatology, 2023
BACKGROUND Interleukin-5 (IL-5) inhibitors represent novel therapies for eosinophilic granulomatosis with polyangiitis (EGPA). This study assessed the effectiveness and safety of the IL-5 receptor inhibitor benralizumab in a European cohort of patients ...
A. Bettiol +49 more
semanticscholar +1 more source
BACKGROUND Interleukin-5 (IL-5) inhibitors represent novel therapies for eosinophilic granulomatosis with polyangiitis (EGPA). This study assessed the effectiveness and safety of the IL-5 receptor inhibitor benralizumab in a European cohort of patients ...
A. Bettiol +49 more
semanticscholar +1 more source
Benralizumab versus Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis.
New England Journal of MedicineBACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by eosinophilic inflammation. Benralizumab, a monoclonal antibody against the interleukin-5α receptor expressed on eosinophils, may be an option for treating ...
Michael E. Wechsler +15 more
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