Abstract Wasting syndrome (WS), also known as unintentional weight loss, is defined as a 5% reduction in body weight over a period of 6–12 months. The mortality associated with WS in older adults has not been adequately explored. The objective of this study was to investigate this relationship in hospitalized older individuals over an 18‐month period ...
Roana Carolina Bezerra dos Santos +7 more
wiley +1 more source
Functional connectivity-based attractor dynamics of the human brain in rest, task, and disease. [PDF]
Englert R +10 more
europepmc +1 more source
Population Pharmacokinetics of the Novel Myeloperoxidase Inhibitor Mitiperstat
ABSTRACT Mitiperstat is a novel myeloperoxidase inhibitor being investigated for the treatment of heart failure, metabolic dysfunction‐associated steatohepatitis, and chronic obstructive pulmonary disease. Pharmacokinetic data from five clinical trials were used to develop a mitiperstat population pharmacokinetics (popPK) model.
Mikael Sunnåker +2 more
wiley +1 more source
Coupling Models of Resistive Valves to Muscle Mechanics in Cardiac Fluid-Structure Interaction Simulations. [PDF]
Bucelli M, Dede L.
europepmc +1 more source
Solar Energetic Particle Prediction in the Inner Heliosphere Using Deep Learning and PSP/IS⊙IS Data
Abstract Solar events, such as coronal mass ejections and solar flares, accelerate large numbers of energetic charged particles, producing solar energetic particle (SEP) events that can harm astronauts, damage satellites, and potentially damage infrastructure on Earth.
Tate Hutchins +12 more
wiley +1 more source
Impact of Four-Phonon Scattering on Thermal Transport and Thermoelectric Performance of Penta-XP<sub>2</sub> (X = Pd, Pt) Monolayers. [PDF]
Lan Y +11 more
europepmc +1 more source
This study investigates the spatial disorder, or entropy, of functional brain networks in older and younger adults. The authors find that brain spatial entropy is higher in older adults than in younger adults and that higher entropy in brain regions responsible for motor control is associated with worse physical function.
Clayton C. McIntyre +6 more
wiley +1 more source
Stereoselective Cytotoxicity of Enantiopure 3,3-Dichloro-γ-lactams: Correlating In Vitro Activity with In Vivo Tolerability. [PDF]
Diaba F, Teixidó E, Morán MDC.
europepmc +1 more source
Association of GLP‐1 Receptor Agonists With Hepatic Decompensation in the All of Us Research Program
ABSTRACT Aims To evaluate the association between glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) initiation and the risk of hepatic decompensation compared with dipeptidyl peptidase 4 inhibitors (DPP4is) in a racially and ethnically diverse cohort of adults with Type 2 diabetes.
Inyoung Hwang, Yun Kim, Sang Won Lee
wiley +1 more source
Specialized aldo-keto reductases trigger complete degradation of mycotoxin deoxynivalenol. [PDF]
He W +20 more
europepmc +1 more source

