Results 71 to 80 of about 55,561 (264)

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Evaluating clinical AI summaries with large language models as judges

npj Digital Medicine
Electronic Health Records (EHRs) contain vast clinical data that are difficult for providers to synthesize. Generative AI with Large Language Models (LLMs) can summarize records to reduce cognitive burden, but ensuring accuracy requires reliable ...
Emma Croxford, Yanjun Gao, Elliot First, Nicholas Pellegrino, Miranda Schnier, John Caskey, Madeline Oguss, Graham Wills, Guanhua Chen, Dmitriy Dligach, Matthew M. Churpek, Anoop Mayampurath, Frank Liao, Cherodeep Goswami, Karen K. Wong, Brian W. Patterson, Majid Afshar   +16 more
doaj   +1 more source

Psychometric properties of the expanded prostate cancer index composite - 26 instrument in a cohort of radical prostatectomy patients: theoretical and practical examinations

BMC Urology, 2017
Background Recently, the Expanded Prostate Cancer Index Composite 26-item version (EPIC-26) was recommended for the assessment of adverse effects after the treatment of prostate cancer without clear reasons.
Karol Axcrona, Rasmus Nilsson, Bjørn Brennhovd, Øystein Sørebø, Sophie D. Fosså, Alv A. Dahl   +5 more
doaj   +1 more source

MicroCT reinvestigation of the only articulated fossil anostomid fish reveals synonymy of Arhinolemur Ameghino, 1898 and Megaleporinus Ramirez et al., 2017

The Anatomical Record, EarlyView.
Abstract Arhinolemur scalabrinii† Ameghino, 1898 was originally described as a strepsirrhine primate (Mammalia) but has been recognized as an anostomid fish since 2012. It remains the only extinct anostomid species known from complete cranial material.
Karen M. Panzeri, Humberto L. Andrelino, Sergio Bogan, José P. O'Gorman, Federico Agnolín, Brian L. Sidlauskas, Nahuel Vega, Agustín G. Martinelli, José L. Birindelli   +8 more
wiley   +1 more source

Ultrasound‐Guided Hip Pericapsular, Rectus Femoris Peritendinous, and Iliopsoas Bursa Injections Improve Extra‐articular Post‐arthroscopy Hip Pain

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To determine the short‐ and medium‐term efficacy of ultrasound‐guided hip pericapsular, rectus femoris peritendinous, and iliopsoas bursa injections with anesthetic and corticosteroid to treat post‐arthroscopy hip pain, and if any operative variables correlated with response likelihood.
Meghan E. Sahr, Hanley Ong, Karthik Krishnan, Shu‐Han Wang, Danyal H. Nawabi, Theodore T. Miller   +5 more
wiley   +1 more source

A Pragmatic Trial of a Shared Decision‐Making Intervention to Improve Medication Adherence and Outcomes in Systemic Lupus Erythematosus: The HCQ‐SAFE Study

Arthritis &Rheumatology, EarlyView.
Objective Hydroxychloroquine (HCQ) nonadherence in systemic lupus erythematosus (SLE) stemming from decision complexities can be improved with shared decision‐making (SDM) tools clarifying benefits and harms. This study aimed to develop and evaluate HCQ‐SAFE, a pictogram‐based SDM tool during SLE visits.
Caroline Packee, Jay J. Patel, Jessica Kent, Betty Chewning, Sancia Ferguson, Patricia Tellez‐Giron, David Gazeley, Christie M. Bartels, Shivani Garg   +8 more
wiley   +1 more source

Bridging the Evidence-to-Policy Gap: Strengthening Capacities in Low- and Middle-Income Countries to Translate Antimicrobial Resistance Data and Evidence into Effective Policies

Antibiotics
Background: The translation of antimicrobial resistance (AMR) data and evidence into policy remains limited in many low- and middle-income countries (LMICs) in Asia and Africa, despite expanded investments being made in AMR surveillance and research ...
Prerana Parajulee, Sajan Gunarathna, Anthony Burnett, Jae Hee Hwang, Jung-Seok Lee, Fadi El-Jardali, Satyajit Sarkar   +6 more
doaj   +1 more source

Patients on statins with elevated transaminases: Frequency of follow‐up creatine kinase testing and gastroenterology referral

British Journal of Clinical Pharmacology, EarlyView.
Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh, Anas Kartoumah, Rajshri Joshi, Anjali Nadihaan, Mohammed Mouchli, Inderprit Singh   +5 more
wiley   +1 more source

Identification of antibiotic allergies in children using prescribing patterns in the electronic medical record

British Journal of Clinical Pharmacology, EarlyView.
Background By age three, 5%–75% of children have a documented antibiotic allergy (AL). Despite this prevalence, recognition remains low because of limited clinician knowledge and time. Our study evaluates a novel approach to identifying AL using electronic medical record (EMR) prescription patterns.
Georgia Koutsaplis, Kailey Tang, Renee Dimond, Alice Lei, Amanda Wilkins, Amanda Gwee   +5 more
wiley   +1 more source

Cognition in Chronic Heart Failure: Advancing Knowledge for Better Prevention Through Remote Assessment

CJC Open
Background: Cognitive impairment is an important comorbidity of chronic heart failure (CHF) and may be associated with major complications. Despite ongoing advances in research and clinical management, early identification and prevention of cognitive ...
Caroll-Ann Blanchette, MSc, Florent Besnier, PhD, Josep Iglesies Grau, MD, PhD, Emma Gabrielle Dupuy, PhD, Christine Gagnon, PsyD, PhD, Thomas Vincent, PhD, Jean-Lucien Rouleau, MD, Normand Racine, MD, François Tournoux, MD, PhD, Paolo Vitali, MD, PhD, FRCPC, Sylvie Belleville, PhD, Francisco J. Apullan, MD, Louis Bherer, PhD   +12 more
doaj   +1 more source