Results 111 to 120 of about 14,206,160 (302)

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Mobility between communities can reduce the impact of measles intervention during an outbreak: a mathematical modeling study

Frontiers in Public Health
Measles resurgence has occurred in a number of settings this year where elimination had been declared. Although under-vaccination of the community is the principal reason for the resurgence additional factors confound this further including community ...
Michael A. Irvine, Michael A. Irvine, Michael A. Irvine, Kari Harder, Prital Patel, Prital Patel, Agatha Jassem, Agatha Jassem, Megan R. Edwards, Elaine Chan, Jia Hu, Jennifer Vines, Trevor Corneil, Trevor Corneil, Tribesty Nguyen, Tribesty Nguyen, Hind Sbihi, Hind Sbihi   +17 more
doaj   +1 more source

A Study on Formal Methods to Generalize Heterogeneous Mobile Malware Propagation and Their Impacts

IEEE Access, 2017
Mobile personal devices, such as smartphones, USB thumb drives, and sensors, are becoming essential elements of our modern lives. Their large-scale pervasive deployment within the population has already attracted many malware authors, cybercriminals, and
Arash Mahboubi, Seyit Camtepe, Hasmukh Morarji   +2 more
doaj   +1 more source

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Do consumers and healthcare professionals report the same adverse event differently? A paired analysis of duplicate vaccine safety reports in Norway

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to compare how Norwegian healthcare professionals (HCPs) and consumers reported the same adverse event (AE) following immunization with vaccines against COVID‐19 during the COVID‐19 pandemic. Specifically, we aimed to compare the extent to which HCPs and consumers reported information relevant for assessing the causal relationship ...
Tommy Emil Dzus, Johaina Sarrage, Hilde Samdal, François Montastruc, Elena Rocca   +4 more
wiley   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Mathematical modelling of COVID-19 dynamics using SVEAIQHR model

Computational and Mathematical Biophysics
In this study, we formulate an eight-compartment mathematical model with vaccination as one of the compartments to analyze the dynamics of COVID-19 transmission.
Venkatesh Ambalarajan, Rao Mallela Ankamma, Raj Murugadoss Prakash, Kumar Karuppusamy Arun, Vamsi D. K. K.   +4 more
doaj   +1 more source

Medicines, misinformation and machines: Navigating infodemics in the generative AI era

British Journal of Clinical Pharmacology, EarlyView.
Health information is now widely accessed through smartphones, online searches and increasingly through generative artificial intelligence (AI). These systems create new opportunities for communication, and in some routine contexts, well‐governed AI assistants could reduce exposure to lower quality sources by providing cautious, evidence‐aligned ...
Natansh D. Modi, Lisa M. Kalisch Ellett, Michael D. Wiese, Ashley M. Hopkins   +3 more
wiley   +1 more source

A theoretical framework for agent-based modelling of infectious disease dynamics under misinformation and vaccine hesitancy

Радіоелектронні і комп'ютерні системи
The relevance of this study stems from the growing importance of modelling not only the biological transmission of infectious diseases but also the behavioural and informational factors that shape real-world epidemic dynamics. The subject of the research
Dmytro Chumachenko
doaj   +1 more source