Results 71 to 80 of about 453,209 (245)

Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia

Malaria Journal, 2022
Background Routine monitoring of anti-malarial drugs is recommended for early detection of drug resistance and to inform national malaria treatment guidelines. In Ethiopia, the national treatment guidelines employ a species-specific approach.
Ashenafi Assefa, Hussein Mohammed, Anjoli Anand, Adugna Abera, Heven Sime, Anna A. Minta, Mekonnen Tadesse, Yehualashet Tadesse, Samuel Girma, Worku Bekele, Kebede Etana, Bereket Hailegiorgis Alemayehu, Hiwot Teka, Dereje Dilu, Mebrahtom Haile, Hiwot Solomon, Leah F. Moriarty, Zhiyong Zhou, Samaly Souza Svigel, Bryan Ezema, Geremew Tasew, Adugna Woyessa, Jimee Hwang, Matthew Murphy   +23 more
doaj   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Incidence rate of hemorrhagic fever with renal syndrome complicated with acute pancreatitis: a meta-analysis

Frontiers in Medicine
BackgroundAcute pancreatitis (AP) is a rare but serious complication in patients diagnosed with hemorrhagic fever with renal syndrome (HFRS). When AP complicates HFRS, the clinical outcome significantly worsens and the risk of mortality increases ...
Zhenzhen Ye, Zhenzhen Ye, Xiaoqing Liu, Xiaoqing Liu, Sheng Ding, Sheng Ding, Ling Lu, Tianchen Zhang, Tianchen Zhang, Wenfang Zhou, Wenfang Zhou, Yonghai Dong, Yonghai Dong   +12 more
doaj   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Epidemiological investigation of the 119th confirmed Middle East Respiratory Syndrome coronavirus case with an indefinite mode of transmission during the Pyeongtaek outbreak in Korea [PDF]

Epidemiology and Health, 2015
Since the first case was diagnosed on May 20, 2015, there were 186 confirmed cases of Middle East Respiratory Syndrome (MERS) until the end of outbreak in South Korea.
Jong Hyuk Choi, Byoungin Yoo, Soon Young Lee, Eun Gyu Lee, Moran Ki, Woncheol Lee, Jong Rak Jung, Kyujin Chang   +7 more
doaj   +1 more source

Getting to Zero HIV Cases San Francisco: Reconceptualizing Housing as HIV Prevention and HIV Treatment [PDF]

, 2019
The City and County of San Francisco, originallyground zero for the HIV epidemic in the United States, is redefining public health HIV interventions, potentially positioning San Francisco as one of the first major metropolitan cities in the world to ...
Zaragoza, Gaspar
core  

Financing structural interventions: going beyond HIV-only value for money assessments.

, 2014
OBJECTIVE: Structural interventions can reduce HIV vulnerability. However, HIV-specific budgeting, based on HIV-specific outcomes alone, could lead to the undervaluation of investments in such interventions and suboptimal resource allocation.
Luna, Jorge, Lutz, Brian, Remme, Michelle, Vassall, Anna, Watts, Charlotte   +4 more
core   +1 more source

Identification of Mannose‐Capped‐Arabinomannan 101‐mer as a Potential Influenza Virus Vaccine Adjuvant

Advanced Science, EarlyView.
Well‐defined and synthetic mannose‐capped arabinomannan 101‐mer from Mycobacterium tuberculosis cell wall was identified as a potent influenza vaccine adjuvant, boosting the antibody response, realizing full protection and showing excellent safety. ABSTRACT Many natural bacterial components as adjuvants can activate the host immune system, but the ...
Yu‐Fang Zhang, Ruihong Xu, Jia Luo, Yuxin Ma, Guozhi Xiao, Ye Liu   +5 more
wiley   +1 more source

Optimal control of diphtheria epidemic model with prevention and treatment

Journal of Physics: Conference Series, 2020
Abstract Diphtheria is an infectious and deadly disease that spread through droplet transmission. Nevertheless, diphtheria can be prevented by immunization. One of many ways to gain immunity against the disease is by getting a vaccine.
N Izzati, A Andriani, R Robi’aqolbi
openaire   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source