Results 61 to 70 of about 1,195,086 (384)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Do medical conditions predispose to the development of chronic back pain? A longitudinal co-twin control study of middle-aged males with 11-year follow-up

BMC Musculoskeletal Disorders, 2018
Background Poor general health predicts the transition to chronic back pain (CBP), but the role of specific medical conditions in the development of CBP is unclear.
Pradeep Suri, Edward J. Boyko, Sean D. Rundell, Nicholas L. Smith, Jack Goldberg   +4 more
doaj   +1 more source

Race composition and genetic diversity of a Puccinia striiformis f. sp. tritici population from Yunnan and Guizhou epidemiological regions in China in 2018 [PDF]

, 2022
Wen Chen, Zedong Zhang, Ye Tian, Zhensheng Kang, Jie Zhao   +4 more
openalex   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Prescription opioid dispensing patterns among patients with schizophrenia or bipolar disorder

BMC Psychiatry
Background Patients with schizophrenia (SZ) or bipolar disorder (BD) may have increased risk of complications from prescribed opioids, including opioid-induced respiratory depression.
Brittany D. Roy, Jianheng Li, Cathy Lally, Sarah C. Akerman, Maria A. Sullivan, James Fratantonio, William Dana Flanders, Madé Wenten   +7 more
doaj   +1 more source

Effects of physical activities on dementia‐related biomarkers: A systematic review of randomized controlled trials

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Physical activities (PA) may lead to improved cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), and dementia. The mechanisms mediating potential PA effects are unknown.
Mohammad Moniruzzaman, Aya Kadota, Maksudul Shadat Akash, Patrick J Pruitt, Katsuyuki Miura, Roger Albin, Hiroko H. Dodge   +6 more
doaj   +1 more source

Differential trends in the compression of mortality: Assessing the antecedents to current gaps in health expectancy in New Zealand [PDF]

, 2009
Health Expectancies (HEs) for New Zealand show significant differentials between Maori and non-Maori, but also by gender and period. These differentials correlate with findings from both generation and synthetic life-tables relating to New Zealand’s ...
Amey, Ben, Boddington, Bill, Cheung, Jit, Didham, Robert, Pool, Ian   +4 more
core   +1 more source

DSM-5 criteria for substance use disorders: recommendations and rationale. [PDF]

, 2013
Since DSM-IV was published in 1994, its approach to substance use disorders has come under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but concerns have also arisen.
Auriacombe, Marc, Borges, Guilherme, Bucholz, Kathleen, Budney, Alan, Compton, Wilson M, Crowley, Thomas, Grant, Bridget F, Hasin, Deborah S, Ling, Walter, O'Brien, Charles P, Petry, Nancy M, Schuckit, Marc   +11 more
core   +1 more source