Results 31 to 40 of about 205,094 (258)

Estudo longitudinal das crianças nascidas em 1982 em Pelotas, RS, Brasil: metodologia e resultados preliminares Study in length of children born in Pelotas, Rio Grande do Sul, Brazil, in 1982: metodology and preliminary results

open access: yesRevista de Saúde Pública, 1985
Tentou-se acompanhar a morbi-mortalidade e o crescimento de uma coorte de 6.011 crianças urbanas nascidas em 1982 nos hospitais de Pelotas, RS, através de visitas domiciliares aos 12 meses (para uma amostra de 30% das crianças) e aos 20 meses (para toda ...
César Gomes Victora   +4 more
doaj   +1 more source

Cardiovascular diseases mortality in the population of Belgrade aged 30-69 years for 1990-2002 period [PDF]

open access: yesVojnosanitetski Pregled, 2005
During the period between 1990 and 2002 in Belgrade population, almost every second person aged 30-69 years, died of some cardiovascular disease (CVD).
Šipetić Sandra B.   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

For a General Theory of Health: preliminary epistemological and anthropological notes

open access: yesCadernos de Saúde Pública, 2001
In order to conduct a preliminary evaluation of the conditions allowing for a General Theory of Health, the author explores two important structural dimensions of the scientific health field: the socio-anthropological dimension and the epistemological ...
Almeida Filho Naomar de
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Examining qualitative and quantitative features of verbal fluency tasks to investigate the mental lexicon in postpartum women: A neuropsychological approach of executive functions applied to language

open access: yesPsychology of Language and Communication, 2022
During the postpartum period, women experience neurobiological and psychosocial variations that impact language functioning. Word production in verbal fluency tasks (VFTs) is a cognitive indicator of associative (semantic categorization and phonological ...
Barral Paula Eugenia   +4 more
doaj   +1 more source

Epidemiologic Methods in Immunization Programs [PDF]

open access: yesEpidemiologic Reviews, 1996
its safety and efficacy in phased clinical trials. Postlicensure, continued close monitoring of the vaccine's safety and effectiveness is needed, especially early on. But equally important to a vaccine's ultimate success is the close monitoring of the immunization program itself. Surveillance for vaccine coverage, disease incidence, and adequacy of the
R T, Chen, W A, Orenstein
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

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