Results 51 to 60 of about 196,976 (258)
For a General Theory of Health: preliminary epistemological and anthropological notes
Cadernos de Saúde PúblicaIn order to conduct a preliminary evaluation of the conditions allowing for a General Theory of Health, the author explores two important structural dimensions of the scientific health field: the socio-anthropological dimension and the epistemological ...
Naomar de Almeida Filho
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Real-time Estimates in Early Detection of SARS
Emerging Infectious Diseases, 2006 We propose a Bayesian statistical framework for estimating the reproduction number R early in an epidemic. This method allows for the yet-unrecorded secondary cases if the estimate is obtained before the epidemic has ended. We applied our approach to the
Simon Cauchemez +8 more
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FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
An empirical method to cluster objective nebulizer adherence data among adults with cystic fibrosis
Patient Preference and Adherence, 2017 Zhe H Hoo,1,2 Michael J Campbell,1 Rachael Curley,1,2 Martin J Wildman1,2 1School of Health and Related Research (ScHARR), University of Sheffield, 2Sheffield Adult Cystic Fibrosis Centre, Northern General Hospital, Sheffield, UK Background: The ...
Hoo ZH +3 more
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The Number Needed to Treat: 25 Years of Trials and Tribulations in Clinical Research
Rambam Maimonides Medical Journal, 2015 The number needed to treat (NNT) is a simple measure of a treatment’s impact, increasingly reported in randomized trials and observational studies, but often incorrectly calculated in studies involving varying follow-up times. We discuss the NNT in these
Samy Suissa
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Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Exploring analytical pathways for climate change as a threat multiplier
Environmental Research LettersClimate change has been widely conceptualized as a threat multiplier of pre-existing disadvantage, yet quantitative research has lacked a structured framework for empirically testing how climate-related exposures amplify disadvantage–outcome ...
Nadav L Sprague +4 more
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Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Método de captura e recaptura: nova metodologia para pesquisas epidemiológicas
Revista de Saúde PúblicaO método de captura e recaptura, embora não seja novo, tem sido pouco usado em estudos epidemiológicos. Trata-se de método bem adaptável e adequado para estudar populações incomuns ou esquivas, como usuários de drogas endovenosas.
John Dunn, Sérgio Baxter Andreoli
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Study designs: Part 3 - Analytical observational studies
Perspectives in Clinical Research, 2019 In analytical observational studies, researchers try to establish an association between exposure(s) and outcome(s). Depending on the direction of enquiry, these studies can be directed forwards (cohort studies) or backwards (case–control studies).
Priya Ranganathan, Rakesh Aggarwal
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