Results 251 to 260 of about 12,656,369 (300)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Adapting the Eysenck Personality Questionnaire-Revised Neuroticism Scale for Use in Epidemiologic Studies: A Psychometric Evaluation Using Item Response Theory in the UK Biobank

Pflanz CP, Gallacher J, Bauermeister S.
europepmc   +1 more source

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An Epidemiologic Study of NCLEX

Nurse Educator, 1992
This study of NCLEX performance was designed to identify the best risk indices for students who do not pass the test, to pinpoint the earliest time in their academic careers that their risk can substantially be known, and to estimate the effectiveness of a formal review course. Results show that 62% of the variance in NCLEX scores can be predicted with
J B, Younger, M J, Grap
openaire   +2 more sources

Acromegaly: An epidemiological study

Journal of Endocrinological Investigation, 1993
Although morbility and mortality in acromegaly are higher than in the general population, there have been very few previous epidemiological studies. This study tries to answer "why". Seventy-four patients affected by acromegaly in Vizcaya (Spain) between 1970 and 1989 were considered for an epidemiological study.
J, Etxabe, S, Gaztambide, P, Latorre, J A, Vazquez   +3 more
openaire   +2 more sources

An epidemiological study of schizophrenia

Journal of Biosocial Science, 1972
This report is based on the findings of an epidemiological study of 29,468 rural, semi-rural and urban inhabitants of the Agra region of Uttar Pradesh. The survey was made in order to find out the prevalence of severe mental disorders and associated conditions in an Indian community. The sampling was purposive and areas selected were contiguous. Census
K C, Dube, N, Kumar
openaire   +2 more sources

An Epidemiological Study of Tics

Psychiatry and Clinical Neurosciences, 1990
Abstract: We devised a questionnaire for estimation of each tic, and used a two‐step investigation procedure, first by a parent questionnaire with 1,218 responses and second by a confirmatory telephone interview for 197 positive responses. The average estimated values were 11.3% for boys and 5.2% for girls.
F, Nomoto, Y, Machiyama
openaire   +2 more sources

An epidemiological study of hysteria

Journal of Biosocial Science, 1974
SummaryIn a comprehensive epidemiological study conducted by a census survey in a population of 29,468 individuals in the Agra region of Uttar Pradesh, northern India, 261 cases of conversion symptoms in the form of hysterical fits were detected constituting a prevalence rate of 8.9 per thousand (Dube, 1970). The study population consisted of residents
K C, Dube, N, Kumar
openaire   +2 more sources

An epidemiologic study of stuttering

Journal of Communication Disorders, 1994
A questionnaire designed to assess the prevalence of stuttering and its relation with: (a) central nervous system risk factors; (b) associated disorders (allergies, migraine-type headache, developmental dyslexia history, smoking, and drug abuse), and (c) depression symptoms, was given to a general population sample of 1879 Spanish-speaking university ...
A, Ardila, J R, Bateman, C R, Niño, E, Pulido, D B, Rivera, C J, Vanegas   +5 more
openaire   +2 more sources