Results 91 to 100 of about 6,409,377 (315)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Epidemiological characteristics of severe fever with thrombocytopenia syndrome and the relationship with meteorological factors in Jiangsu Province, China

Frontiers in Public Health
BackgroundSevere Fever with Thrombocytopenia Syndrome (SFTS) has become a global public health concern in recent years. The main purpose of this study was to depict the epidemiological characteristics of SFTS in Jiangsu Province, China and evaluate the ...
Yuhao Tao, Wendong Liu, Yin Wang, Shuyi Liang, Xiaochen Wang, Zhifeng Li, Wenxin Gu, Xin Liu, Xinru Zeng, Changjun Bao, Changjun Bao   +10 more
doaj   +1 more source

Epidemiological, clinical and virological characteristics of the cluster patients.

, 2013
Epidemiological, clinical and virological characteristics of the cluster patients.
Tamara Alvaro-Cifuentes (478243), Rosa Fuentes (478245), Lorena Martínez-Prats (478246), Eulalia Grau (331397), Jorge del Romero (247501), Carmen Rodríguez (2228080), Maria Pernas (2228083), Virginia Sandonis (478242), Lidia Ruiz (221142), Isabel Olivares (478244), Concepción Casado (247472), Rafael Delgado (221132), Cecilio López-Galíndez (186333)   +12 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024

Frontiers in Public Health
BackgroundPertussis is a highly contagious disease caused by Bordetella pertussis (BP) and remains endemic worldwide, with cyclic epidemics occurring every 2–5 years.
Miao Liu, Miao Liu, Xiaoling Wei, Xiaoling Wei, Jing Sun, Jing Sun, Yanqin Liu, Yanqin Liu, Lu Cheng, Lu Cheng, Yuling Han, Yuling Han, Xiang Ma, Xiang Ma, Xiang Ma   +14 more
doaj   +1 more source

Clinical and epidemiological characteristics of patients and differences between genders.

, 2018
Clinical and epidemiological characteristics of patients and differences between genders.
Arturo González-Quintela (4966249), Ignacio Novo-Veleiro (3592532), Sergio Rodríguez-Fernández (4966252), Xana García-Fernández (4966255), Vanesa Alende-Castro (4966258), Cristina Macía-Rodríguez (4966246), Mercedes Treviño-Castellano (4966243)   +6 more
core   +1 more source

Baseline epidemiological characteristics of E. coli bacteremia episodes.

, 2020
Baseline epidemiological characteristics of E. coli bacteremia episodes.
Tess D. Verschuuren (8298792), Patricia C. J. Bruijning-Verhagen (8298795), Anita C. Schürch (8298798), Thijs Bosch (223145), Jan A. J. W. Kluytmans (8298804), Denise van Hout (8298789), Rob J. L. Willems (8298801), Marc J. M. Bonten (7439411)   +7 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Epidemiological characteristics of the 2014 West African Ebola outbreak.

, 2015
Epidemiological characteristics of the 2014 West African Ebola outbreak.
Caitlin M. Rivers (749699), John M. Drake (67554), Virginia M. Dato (392802), Jeffrey Shaman (252813), Stephen Eubank (206060), Claire E. Sanderson (749696), Bryan L. Lewis (749698), Marisa C. Eisenberg (749700), Madav Marathe (749697), Kathleen A. Alexander (749695), Eric Lofgren (4331392)   +10 more
core   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source