Results 101 to 110 of about 448,594 (314)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Risk factors associated with severe COVID-19 outcomes in Jamaica: a cross-sectional study of national surveillance data

Revista Panamericana de Salud Pública
Objectives. To describe the characteristics and outcomes of COVID-19 cases in Jamaica and to explore the risk factors associated with severe COVID-19 from 9 March to 31 December 2020. Methods.
Karen Webster-Kerr, Andriene Grant, Ardene Harris, Romae Thorpe, Daidre Rowe, Deborah Henningham, Tanielle Mullings, Iyanna Wellington, Jovan Wiggan, Kelly Ann Gordon-Johnson, Carol Lord, Tonia Dawkins-Beharie, Jemma Azille-Lewis, Jacqueline Duncan   +13 more
doaj   +1 more source

Causation’s Nuclear Future: Applying Proportional Liability to the Price-Anderson Act [PDF]

, 2014
For more than a quarter century, public discourse has pushed the nuclear-power industry in the direction of heavier regulation and greater scrutiny, effectively halting construction of new reactors.
O’Connell, William D.
core   +1 more source

Monitoring response to hepatitis B and C in EU/EEA: testing policies, availability of data on care cascade and chronic viral hepatitis-related mortality – results from two surveys (2016) [PDF]

, 2018
Objectives: The World Health Organization (WHO) developed a European Regional Action Plan (EAP) to fast-track action towards the goal of eliminating viral hepatitis. Robust monitoring is essential to assess national programme performance.
De Brujin, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, European Centre for Disease Prevention and Control, Iyengar, World Health Organisation, World Health Organisation, World Health Organisation   +11 more
core   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Enhancement of Epidemiological Models for Dengue Fever Based on Twitter Data

, 2017
Epidemiological early warning systems for dengue fever rely on up-to-date epidemiological data to forecast future incidence. However, epidemiological data typically requires time to be available, due to the application of time-consuming laboratorial ...
Albinati, Julio, Marques-Toledo, Cecilia, Meira Jr., Wagner, Pappa, Gisele L., Teixeira, Mauro   +4 more
core   +1 more source

Yersinia enterocolitica in Italy. A case of septicemia and abdominal aortic aneurysm infection [PDF]

, 2018
We report a case of Yersinia enterocolitica septicemia in a 63-year-old patient admitted to the Vascular Surgery Department of Umberto I Hospital (Rome, Italy) for an abdominal aortic aneurysm.
Alessia Bressan, Cecilia Ambrosi, Cecilia Ambrosi, Daniela Scribano, Donatella M. Rodio, Francesco Speziale, Guido Antonelli, Maria Trancassini, Rita Tolli, Valeria Pietropaolo, Wassim Mansour   +10 more
core   +2 more sources

Highly Resolved Community Sewage Metagenomics Unveiling Landscape and Transmission Patterns of Antibiotic Resistome in Hong Kong Populations

Advanced Science, EarlyView.
A large‐scale, high‐resolution antimicrobial resistance (AMR) surveillance in Hong Kong community sewage combining short‐ and long‐read sequencing. The resistome profile is comprehensively characterized, and this upstream sampling strategy demonstrated superiority in reflecting the human gut resistome.
Jiahui Ding, Mengying Wang, Xiaoqing Xu, Dou Wang, Xi Chen, Shuxian Li, Xiawan Zheng, You Che, Yu Deng, Tommy T. Y. Lam, Liguan Li, Tong Zhang   +11 more
wiley   +1 more source

Serum lactate to albumin ratio at hospital arrival and neurological outcome of out-of-hospital cardiac arrest: a nationwide multicenter observational study [PDF]

Clinical and Experimental Emergency Medicine
Objective We investigated the possible association between serum lactate to albumin ratio upon hospital arrival and out-of-hospital cardiac arrest (OHCA) outcome.
Toshinari Kawama, Toshihiro Hatakeyama, Takashi Sano, Koki Nakada, Tasuku Matsuyama, Takeyuki Kiguchi, Benjamin W. Berg, Tetsuhisa Kitamura, Hisao Matsushima   +8 more
doaj   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source