Results 121 to 130 of about 448,594 (314)

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Comparison between the MIND-China study and similar international large-scale cohort studies

Chinese Journal of Contemporary Neurology and Neurosurgery
Alzheimer's disease (AD) continuum is characterized by an insidious onset and a continuous disease spectrum, making early identification particularly challenging. Its initiation and progression result from complex interactions among amyloid β-protein (Aβ)
WANG Xiao-yu, DU Yi-feng
doaj   +1 more source

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Surveillance of Non-Malignant Asbestos-Related Diseases in an Exposed Population: A Scoping Review

Annals of Global Health
Background: Asbestos remains a significant global public health issue, with approximately 255,000 deaths attributed to exposure each year, primarily through occupational contact.
Camilo de la Pava-Cortés, Esperanza Peña Torres, Tim Driscoll, Catherine Jones, Jennifer Coles, Shane McArdle, Kim Brislane, Matthew Peters, Guillermo Villamizar, Eduardo Algranti, Arthur Frank   +10 more
doaj   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

No time to wait: A regional model for inter-epidemic vector-borne disease preparedness in the Caribbean

Revista Panamericana de Salud Pública
Vector-borne diseases continue to pose significant and evolving public health threats in the Caribbean. The compounded effects of human travel and migration, climate variability, ecological change, and structural vulnerabilities are intensifying ...
Willy Dunbar, Jenna Indarsingh, Rajesh Ragoo, LaDonna Gulston, Dana Gomez, Charmaine Blades, Anselmo Matthew, Alan Wheeler, Horace Cox   +8 more
doaj   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Modern Features of the Epizootiological and Epidemiological Situation on Hemorrhagic Fever with Renal Syndrome in the Rostov Region

Проблемы особо опасных инфекций
The wide spread of hantavirus infection with a tendency to a constant increase in the number of cases is an urgent concern of practical healthcare worldwide.
E. A. Bereznyak, A. V. Trishina, N. L. Pichurina, Yu. A. Lyubich, O. P. Dobrovol’sky, M. V. Zabashta, A. V. Filipрenko, T. N. Borodina, V. V. Batashev, E. V. Kovalev, N. E. Gaevskaya, N. V. Leonenko   +11 more
doaj   +1 more source

Leprosy and tuberculosis concomitant infection: a poorly understood, age-old relationship [PDF]

, 2014
Historically, archaeological evidence, post-mortem findings and retro- spective analysis of leprosy institutions’ data demonstrates a high observed incidence of concomitant infection with leprosy and tuberculosis (TB).
Anjum, V, Hodgson, J, Murthy, K, Rao, AK, Rao, PS, Rao, PV, Rawson, T, Subbanna, J   +7 more
core  

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source