Results 131 to 140 of about 2,566,864 (251)

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

The Global Epidemiological Transition in Cardiovascular Diseases: Unrecognised Impact of Endemic Infections on Peripheral Artery Disease. [PDF]

J Epidemiol Glob Health, 2022
Agius PA, Cutts JC, Song P, Rudan I, Rudan D, Aboyans V, McDermott MM, Criqui MH, Fowkes FGR, Fowkes FJI.   +9 more
europepmc   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Utility of silhouette showcards to assess adiposity in three countries across the epidemiological transition. [PDF]

PLOS Glob Public Health, 2022
Reese TO, Bovet P, Choo-Kang C, Bedu-Addo K, Forrester T, Gilbert JA, Goedecke JH, Lambert EV, Layden BT, Micklesfield LK, Plange-Rhule J, Rae D, Viswanathan B, Luke A, Dugas LR.   +14 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Epidemiological transition to mortality and refracture following an initial fracture. [PDF]

Elife, 2021
Ho-Le TP, Tran TS, Bliuc D, Pham HM, Frost SA, Center JR, Eisman JA, Nguyen TV.   +7 more
europepmc   +1 more source

Political stability and consensus : Keys to sustainable transition [PDF]

, 2000
saatavissa ainoastaan Internetin kauttaAfter a decade of moving from plan to market economies, variations in the rate of economic reforms and performance are evident for transition countries.For many, stabilisation of economic fundamentals has given way ...
Singh, Rupinder
core  

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Epidemiologic Transition in Iran with Emphasis on the Third Stage of Transition

Journal of Community Health Research, 2017
Introduction: During the last half century, all indices of mortality imply the prompt and continuous decrease of nationwide mortality. Alongside reduction of mortality, there happened a comprehensive form of transition of mortality causes, from ...
mohamad sasanipour, Sajjad Asadi
doaj  

Temporal trends in the burden of non-communicable diseases in countries with the highest malaria burden, 1990-2019: Evaluating the double burden of non-communicable and communicable diseases in epidemiological transition. [PDF]

Global Health, 2022
Li Z, Shi J, Li N, Wang M, Jin Y, Zheng ZJ.   +5 more
europepmc   +1 more source