Results 91 to 100 of about 4,884,991 (300)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Identification of epithelial stem cells in vivo and in vitro using keratin 19 and BrdU

, 2009
Progress in the identification of skin stem cells and the improvement of culture methods open the possibility to use stem cells in regenerative medicine.
Lavoie, Amélie, Larouche, Danielle, Simard-Bisson, Carolyne, Carolyne Simard-Bisson, Claudie Paquet, Amélie Lavoie, Lucie Germain, Germain, Lucie, Paquet, Claudie, Danielle Larouche   +9 more
core   +1 more source

Characterisation and modulation of drug resistance in lung cancer cell lines [PDF]

, 2010
Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp).
Dunne, Gráinne
core   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The development of stomata and other epidermal cells on the rice leaves

, 2012
In the leaves of rice (Oryza sativa), stomatal initials arose from two asymmetric cell divisions and a symmetric division. Guard mother cells (GMCs) and long cells in stomatal files (LCSs) were formed through the first asymmetric division of the ...
L. Luo, W. -Q. Zhou, C. -X. Li, S. -W. Hou, P. Liu   +4 more
core   +1 more source

CD36+-Dendritic Epidermal Cells: A Putative Actor in the Cutaneous Immune System

Cell Transplantation, 1994
In the present study we have investigated by indirect immunofluorescence staining and mixed lymphocyte reaction methods, the localization, distribution, percentage, and the immunological involvement of CD36+- dendritic epidermal cells (CD36+-DECs) in ...
Mahmoud Rouabhia, Nicolas Jobin, Robert Doucet, Julie Bergeron, François A. Auger   +4 more
doaj   +1 more source

A stem cell proliferation burst forms new layers of P63 expressing suprabasal cells during zebrafish postembryonic epidermal development

Biology Open, 2013
Summary Organ growth during development is a highly regulated process with both temporal and spatial constraints. Epidermal stratification is essential for skin growth and development.
Aida Guzman, Jose L. Ramos-Balderas, Samantha Carrillo-Rosas, Ernesto Maldonado   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The mechanism of signal transduction by the GPI anchored Prod 1 protein [PDF]

, 2010
Salamanders such as the red spotted newt Notophthalamus viridescens and the axolotl Ambystoma mexicanum regenerate a number of anatomical structures following injury.
Blassberg, R.A.
core  

TNFR2 is expressed by a discrete subset of epidermal T cells with an IL-17 gene signature during psoriasis.

PLoS ONE
Psoriasis is a chronic skin disease that results in scaly patches and affects 2-3% of people worldwide. Therapeutic treatment targets the TNF-α/IL-17 axis to disrupt keratinocyte hyperproliferation and inflammation.
Jasmine Ahmed, Carolyn Matthews, Patricia Tulloch, William Lawler, Albert Mendoza, Mikaela Rhoiney, Julie M Jameson   +6 more
doaj   +1 more source