Results 41 to 50 of about 544 (135)

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Imaging findings of an epidermoid cyst undergoing malignant transformation

Journal of the Belgian Society of Radiology, 2015
Malignant transformation of epidermoid cyst into squamous cell carcinoma (SCC) is rare. We report the case of a 39-year-old woman presenting with dizziness and cerebellar ataxia.
D Chourmouzi, E Papadopoulou, G Karkavelas, A Drevelegas   +3 more
doaj   +1 more source

Isolation, cytotoxicity evaluation and HPLC-quantification of the chemical constituents from Prangos pabularia. [PDF]

PLoS ONE, 2014
Phytochemical analysis of the dichloromethane:methanol (1:1) extract of root parts of Prangos pabularia led to the isolation of twelve cytotoxic constituents, viz., 6-hydroxycoumarin (1), 7-hydroxycoumarin (2), heraclenol-glycoside (3), xanthotoxol (4 ...
Saleem Farooq, Shakeel-u-Rehman, Nisar Ahmad Dangroo, Dev Priya, Javid Ahmad Banday, Pyare Lal Sangwan, Mushtaq Ahmad Qurishi, Surrinder Koul, Ajit Kumar Saxena   +8 more
doaj   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

The imaging dynamic changes in the malignant transformation of an epidermoid cyst: a case report and literature review

Frontiers in Neurology
Malignant transformation of epidermoid cysts is a rare complication. Most of the previously reported cases have involved postoperative malignant transformations.
Tian Yang, Jibo Hu, Lele Li, Houyun Xu, Caijuan Zhang, Zhilan Huang, Jun Yang, Huiqing Zhang   +7 more
doaj   +1 more source

Giant epidermoid cyst: a rarity or negligence?

The Pan African Medical Journal, 2018
A 35 year old male presented to our outpatient department with a slow growing swelling over the left gluteal region for more than 10 years. There was no history of pain, tenderness, fever or previous trauma.
Rakesh Sharma, Biren Padhy
doaj   +1 more source

Incidental Colorectal Adenomas in Adolescents: Clinical Management, Genetic Evaluation, and Surveillance

Journal of Gastroenterology and Hepatology, EarlyView.
Adolescents with incidental colorectal adenomas require age‐conscious management balancing referral for genetic counseling with evidence‐based surveillance. This narrative review proposes a pragmatic clinical algorithm integrating adenoma characteristics, hereditary risk assessment, and guideline‐concordant follow‐up to support individualized ...
Brett J. Hoskins, Shlomi Cohen, Colleen B. Flahive, Isabel Rojas, Aparajita Singh, Thomas M. Attard   +5 more
wiley   +1 more source

Clinicopathological and Prognostic Features of Pleomorphic Adenoma, Recurrent Pleomorphic Adenoma, and Carcinoma ex Pleomorphic Adenoma: A 20‐Year Retrospective Analysis

Oral Diseases, EarlyView.
ABSTRACT Background Pleomorphic adenoma (PA) is the most common salivary gland tumor, and a subset may recur as recurrent PA (RPA) or progress to carcinoma ex pleomorphic adenoma (CXPA). However, comparative evaluations of their biological behavior and prognostic factors remain limited.
Talita de Carvalho Kimura, Luccas Lavareze, Reydson Alcides de Lima‐Souza, Nívia Castro Binda, Carlos Takahiro Chone, Alfio José Tincani, Albina Altemani, Fernanda Viviane Mariano   +7 more
wiley   +1 more source

Carcinoma in Split Skin Graft

Indian Journal of Plastic Surgery, 1977
Two cases of epidermoid carcinoma following surface SSG-one over the right leg and another over the scalp are reported here, Such a complication should be carefully looked for and kept in mind during followup in all skin grafts.
R. K. Keswani, R. L. Jain, J. S. Beniwal, Kumar Sunil   +3 more
doaj   +1 more source

Design and characterization of camptothecin gel for treatment of epidermoid carcinoma

Future Journal of Pharmaceutical Sciences, 2020
Background The objective of present research work is to design and characterize camptothecin gel using Carbopol-934 for the treatment of epidermoid carcinoma.
Sunil T. Galatage, Aditya S. Hebalkar, Raviraj V. Gote, Omkar R. Mali, Suresh G. Killedar, Durgacharan A. Bhagwat, Vijay M. Kumbhar   +6 more
doaj   +1 more source