Results 51 to 60 of about 42,895 (279)

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Endobody: Genetically Encodable Nanobody‐CPP Chimeras for Degradation of Membrane and Extracellular Proteins

Advanced Science, EarlyView.
We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou, Huiping He, Simin Xia, Xi Chen   +3 more
wiley   +1 more source

Monthly changes in testes and epididymis measurements with some semen characteristics of tail epididymis for Iraqi buffalo

The Iraqi Journal of Veterinary Medicine, 2012
The present study was carried out to investigate the reproductive activity of mature buffalo bull and months changes on the testes and epididymis. Two hundred and fifty ( 250) testes of mature buffalo bull were collected from the slaughter house east ...
Mohammed Mehdi AL-Sahaf
doaj   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

A Metabolomic Profile of Seminal Fluid in Extremely Severe Oligozoopermia Suggesting an Epididymal Involvement

Metabolites, 2022
Male infertility has increased in the last decade. Pathophysiologic mechanisms behind extreme oligospermia (EO) are not yet fully understood. In new “omics” approaches, metabolomic can offer new information and help elucidate these mechanisms.
Orianne Serri, Magalie Boguenet, Juan Manuel Chao de la Barca, Pierre-Emmanuel Bouet, Hady El Hachem, Odile Blanchet, Pascal Reynier, Pascale May-Panloup   +7 more
doaj   +1 more source

LXR regulate cholesterol homeostasis in the proximal mouse epididymis.

, 2010
Oxysterol nuclear receptors liver x receptors (LXRalpha and LXRbeta) regulate lipid homeostasis when cells have to face high amounts of cholesterol and/or fatty acids.
Ouvrier, AurĂŠlia; Team "epididymis and sperm maturation", UniversitĂŠ Blaise Pascal, UMR GReD CNRS 6247, INSERM U931, Cadet, RĂŠmi, Lobaccaro, Jean-Marc A, Saez, Fabrice, Drevet, JoĂŤl R   +4 more
core   +1 more source

Developmental morphology of claspers and clasper‐glands during maturation in Potamotrygon wallacei (Chondrichthyes: Potamotrygoninae)

The Anatomical Record, EarlyView.
Abstract The claspers are the copulatory organs in male elasmobranchs, responsible for directing the semen into the female cloaca (C). However, the microscopic morphology of the claspers remains poorly understood. This study describes the morphology of the claspers and clasper glands (CGs) of cururu stingray (Potamotrygon wallacei) at different ...
Matheus Samuel Cunha Braga, Grazyelle Sebrenski da Silva, Maria Inês Braga de Oliveira, Jaydione Luiz Marcon, Ruben Dario Morales Gamba   +4 more
wiley   +1 more source

Effect of alcoholic extract of soy bean consumption by pregnant mice on the testis and epididymis of their male offspring's

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2013
Soy is flavones are phytoestrogens with potential hormonal activity due to their similar chemical structure to 17-B-estradiol. The increasing availability of Soy is flavones throughout the food supply and through use of supplements has prompted ...
Abeer Salih Ali, Nisreen Khazal Flayyih, Hadeel Mohammed Qasim   +2 more
doaj   +1 more source

Modern competency‐based teaching of human sexual development

Anatomical Sciences Education, EarlyView.
Abstract Embryology is an integral part of anatomy and a key subject in basic medical education. The development of the sexual tract, which is closely associated with the formation of the urinary tract and the organs of continence, is particularly complex and relevant for many medical disciplines.
Elisabeth Eppler, Alessandro Bilella, Christian M. Hammer   +2 more
wiley   +1 more source