Results 1 to 10 of about 11,440 (156)

The impact of Pleistocene glaciations and environmental gradients on the genetic structure of Embothrium coccineum

open access: yesEcology and Evolution, 2022
The South American temperate forests were subjected to drastic topographic and climatic changes during the Pliocene‐Pleistocene as a consequence of the Andean orogeny and glacial cycles. Such changes are common drivers of genetic structure and adaptation.
Francisco Sepúlveda‐Espinoza   +6 more
doaj   +2 more sources

Phosphorylation of Phylogenetically Conserved Amino Acid Residues Confines HBx within Different Cell Compartments of Human Hepatocarcinoma Cells

open access: yesMolecules, 2021
Hepatitis B virus (HBV) is a circular, and partially double-stranded DNA virus. Upon infection, the viral genome is translocated into the cell nucleus, generating the covalently closed circular DNA (cccDNA) intermediate, and forming a mini chromosome ...
Cristian Prieto   +7 more
doaj   +1 more source

A Green Light to Switch on Genes: Revisiting Trithorax on Plants

open access: yesPlants, 2022
The Trithorax Group (TrxG) is a highly conserved multiprotein activation complex, initially defined by its antagonistic activity with the PcG repressor complex.
Diego Ornelas-Ayala   +6 more
doaj   +1 more source

La epigenética en la diabetes mellitus tipo 2: una enfermedad crónica no transmisible

open access: yesRevista de la Alad. Asociación Latinoamericana de Diabetes, 2021
La diabetes mellitus tipo 2 continúa siendo una pandemia sin aparente solución. Estudios realizados en las últimas dos décadas han encontrado una relación importante entre la epigenética y la diabetes mellitus tipo 2, determinando que el ambiente en el ...
Alexandro J. Martagón-Rosado
doaj   +1 more source

Adverse childhood experiences and developmental disabilities: risks, resiliency, and policy

open access: yesDevelopmental Medicine &Child Neurology, Volume 63, Issue 10, Page 1149-1154, October 2021., 2021
Thanks to the seminal work of Robert Anda and Vincent Felitti, it is now widely accepted that adverse childhood experiences (ACEs) can have lifelong effects on physical, behavioral, and mental health and that many adult diseases can be considered developmental disorders that began early in life.
Kiley Morgart   +3 more
wiley   +1 more source

Meta‐analysis of genome‐wide DNA methylation and integrative omics of age in human skeletal muscle

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 12, Issue 4, Page 1064-1078, August 2021., 2021
Abstract Background Knowledge of age‐related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large‐scale epigenome‐wide association study meta‐analysis of age in human skeletal muscle from 10 studies (total n = 908 muscle methylomes from men and women aged 18–89 ...
Sarah Voisin   +27 more
wiley   +1 more source

DE CE ESTE EPIGENETICA IMPORTANTĂ PENTRU PEDIATRIE? [PDF]

open access: yesRomanian Journal of Pediatrics, 2016
Înţelegerea schimbărilor de patologie din ultimele decade a devenit posibilă datorită achiziţiilor epigenetice. Această ramură a geneticii explică cum influenţează mediul funcţionarea dinamică a genelor.
Sorin Buzinschi
doaj   +1 more source

Epigenética y estilos de vida saludables de la Enfermedad Arterial Periférica

open access: yesEntramado, 2022
La Enfermedad Arterial Periférica (EAP) se caracteriza por la oclusión progresiva de las arterias de las extremidades inferiores, afectando a gran parte de la población mundial.
Ingrid Johana Ángel-Solarte   +4 more
doaj   +1 more source

Papel de las adaptaciones epigenéticas en el riesgo de enfermedades cardiovasculares en la población latinoamericana

open access: yesRevista Med, 2011
<p>Las enfermedades cardio-metabólicas (obesidad, diabetes mellitus tipo 2, infarto agudo de miocardio y accidente cerebro-vascular) son al momento el problema de salud pública más relevante en Colombia. La rápida urbanización experimentada por el país en los últimos 50 años, así como los cambios en los hábitos nutricionales y en la actividad ...
López-Jaramillo, Patricio   +6 more
openaire   +5 more sources

Classical and alternative macrophages have impaired function during acute and chronic HIV-1 infection

open access: yesBrazilian Journal of Infectious Diseases, 2017
Objectives: Three decades after HIV recognition and its association with AIDS development, many advances have emerged – especially related to prevention and treatment.
Leonardo J. Galvão-Lima   +7 more
doaj   +1 more source

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