Results 121 to 130 of about 486,968 (249)

CRISPR/Cas9‐Assisted Microrobots for Fast and Ultrasensitive “On‐The‐Fly” Next‐Generation DNA Detection

Advanced Functional Materials, EarlyView.
This work presents self‐propelled CRISPR/Cas9‐functionalized Au–MRs for rapid, amplification‐free, “on‐the‐fly” DNA detection. By harnessing motion‐assisted signal recovery, the platform achieved the limit of detection in low fM DNA concentrations, enabling detection across a wide dynamic range within only 5 min, which is significantly faster than any ...
Jyoti, Petr Michálek, Zbyněk Heger, Martin Pumera   +3 more
wiley   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

ARID2-related disorder: further delineation of the clinical phenotype of 27 novel individuals and description of an epigenetic signature [PDF]

Clara Houdayer, Kathleen Rooney, Liselot van der Laan, Céline Bris, Mariëlle Alders, Angela Bahr, Giulia Barcia, Clarisse Battault, Anaïs Begemann, Dominique Bonneau, Antoine Bonnevalle, Aïcha Boughalem, Alice Bourges, Marie Bournez, Ange‐Line Bruel, Daniela Buhaş, Floriane Carallis, Benjamin Cogné, Valérie Cormier‐Daire, Julian Delanne, Tanguy Demaret, Anne‐Sophie Denommé‐Pichon, Julie Désir, Christèle Dubourg, Mélanie Fradin, David Geneviève, Himanshu Goel, Alice Goldenberg, Karen W. Gripp, Agnès Guichet, Anne Guimier, Adeline Jacquinet, Boris Keren, Louis Legoff, Michael A. Levy, Haley McConkey, Bryce A. Mendelsohn, Cyril Mignot, Vincent Milon, Mathilde Nizon, Beatrice Oneda, Laurent Pasquier, Olivier Patat, Christophe Philippe, Vincent Procaccio, Rebecca Procopio, Clément Prouteau, Thomas Rambaud, Anita Rauch, Raissa Relator, Sophie Rondeau, Gijs W.E. Santen, Jennifer Schleit, Arthur Sorlin, Katharina Steindl, Matthew L. Tedder, Marine Tessarech, Frédéric Tran Mau‐Them, Detlef Trost, Pleuntje J. van der Sluijs, Marie Vincent, Sandra Whalen, Christel Thauvin‐Robinet, Bertrand Isidor, Bekim Sadiković, Antonio Vitobello, Estelle Colin   +66 more
openalex   +1 more source

Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology

Advanced Healthcare Materials, EarlyView.
In vitro breast cancer models that closely mimic the complex biological and cellular interactions within the tumor microenvironment hold strong promise for enhancing our understanding of tumor progression, immune system behavior, and resistance to therapies, which are essential for developing personalized cancer treatments. Abstract Engineered in vitro
Wonwoo Jeong, Sang Jin Lee
wiley   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Advanced Healthcare Materials, EarlyView.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro   +12 more
wiley   +1 more source

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins [PDF]

, 2012
William W. Lockwood, Kreshnik Zejnullahu, James E. Bradner, Harold Varmus   +3 more
openalex   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

PB2480: LENTIVIRAL LABELING OF STROMAL LAYER OF LONG-TERM BONE MARROW CULTURE DEMONSTRATED INEFFICIENCY FOR MESENCHYMAL STEM CELLS AND CONTRIBUTION OF NON-STEM CELLS TO HEMATOPOIETIC ECTOPIC FOCUS IN MICE

HemaSphere, 2023
Dmitriy Karpenko, Aleksei Bigildeev
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source