Results 141 to 150 of about 486,968 (249)

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Resistance of first-line targeted drugs in hepatocellular carcinoma: the epigenetic regulation mechanisms. [PDF]

Cell Death Dis
Qi D, Qin Y, Zhu H, Li Y, Han S.
europepmc   +1 more source

Additional file 5: of Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

, 2019
Olivia Cypris, Joana Frobel, Shivam Rai, Julia Franzen, Stephanie Sontag, Roman Goetzke, Marcelo Szymanski de Toledo, Martin Zenke, Wolfgang Wagner   +8 more
openalex   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

Epigenetic signatures, age acceleration, and injury risk in elite female and male soccer players. [PDF]

Sci Rep
Pérez RF, Lecumberri-Arteta J, Kulis M, Botta-Orfila T, Rodríguez-Vilarrupla A, Yanguas X, Ferrer E, Rodas G, Martin-Subero JI.   +8 more
europepmc   +1 more source

MOESM4 of H3K4me2 functions as a repressive epigenetic mark in plants

, 2019
Yuhao Liu, Kunpeng Liu, Liufan Yin, Yu Yu, Ji Qi, Wen‐Hui Shen, Jun Zhu, Yijing Zhang, Aiwu Dong   +8 more
openalex   +1 more source

Epigenetic patterns within the haplotype phased fig (Ficus carica L.) genome [PDF]

, 2019
Gabriele Usai, Flavia Mascagni, Tommaso Giordani, Alberto Vangelisti, Emanuele Bosi, Andrea Zuccolo, Marilena Ceccarelli, Robert C. King, Keywan Hassani‐Pak, Liceth Solorzano Zambrano, Andrea Cavallini, Lucia Natali   +11 more
openalex   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Unraveling the causal association of epigenetic age acceleration with common oral diseases and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis. [PDF]

Clin Epigenetics
Peng L, Nie S, Sun Y, Wang S, Wang Y, Liu Z.   +5 more
europepmc   +1 more source

Battle of epigenetic proportions: comparing Illumina’s EPIC methylation microarrays and TruSeq targeted bisulfite sequencing [PDF]

, 2019
Jonathan Heiss, Kasey Brennan, Andrea Baccarelli, Martha María Téllez‐Rojo, Guadalupe Estrada‐Gutiérrez, Robert O. Wright, Allan C. Just   +6 more
openalex   +1 more source