Results 271 to 280 of about 849,922 (340)

Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study. [PDF]

Front Aging
Sayer M, Ng DQ, Trudeau J, Chan RJ, Acharya MM, Kober K, Chan A.   +6 more
europepmc   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Unraveling the causal association of epigenetic age acceleration with common oral diseases and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis. [PDF]

Clin Epigenetics
Peng L, Nie S, Sun Y, Wang S, Wang Y, Liu Z.   +5 more
europepmc   +1 more source

Characterization of 3(3,4-dihydroxy-phenyl) propionic acid as a novel microbiome-derived epigenetic modifier in attenuation of immune inflammatory response in human monocytes

, 2020
Jun Wang, Jennifer Blaze, Fatemeh Haghighi, Seunghee Kim‐Schulze, Urdhva Raval, Kyle J. Trageser, Giulio Maria Pasinetti   +6 more
openalex   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation

Advanced Science, EarlyView.
MSC‐EVs alleviate peritoneal inflammation and fibrogenesis by disrupting the H3K18la‐CCL2 axis and crosstalk between mesothelial cells and Ly6c2⁺ macrophages. Model cartoons are constructed using the Biorender website (https://www.biorender.com/), and a usage license is obtained. Abstract Peritoneal dialysis (PD), as a renal replacement therapy, relies
Qiang Huang, Yuxiang Sun, Pengpeng Kuang, Juan Sun, Dandan Guo, Long Peng, Hu Zhou, Qinrong Song, Zhihao Huo, Canming Li, Janusz Witowski, Zhaoyong Hu, Hui Peng   +12 more
wiley   +1 more source

Changes in nuclear and mitochondrial DNA methylation in cow blood associated with age and disease. [PDF]

Epigenetics
Bouzeraa L, de Lima CB, Martin H, Marques JCS, Cerri R, Oudihat M, Sirard MA.   +6 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Beyond neuronal loss: epigenetic signatures bridging immune activation and sleep dysfunction in narcolepsy type 1. [PDF]

Sleep
BaHammam AS.
europepmc   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Methylation Status of the DAT1 Dopamine Transporter Gene in Individuals With Cannabis Use Disorder: Associations With Personality Traits. [PDF]

Genes Brain Behav
Suchanecka A, Recław R, Chmielowiec K, Chmielowiec J, Masiak J, Grzywacz A.   +5 more
europepmc   +1 more source