Results 41 to 50 of about 33,305 (301)
Bypassing the Blood–Brain Barrier: Direct Intracranial Drug Delivery in Epilepsies
Pharmaceutics, 2020 Epilepsies are common chronic neurological diseases characterized by recurrent unprovoked seizures of central origin. The mainstay of treatment involves symptomatic suppression of seizures with systemically applied antiseizure drugs (ASDs).
Manuela Gernert, Malte Feja
doaj +1 more source
Genetic epilepsies. remarks on the proposed "organization of the Epilepsies"
, 2017 Introduction. Genetic findings in several epilepsy syndromes provide insights into the pathophysiology of specific subtypes of epilepsy and into mechanisms of epileptogenesis, because the genes encoding ion channels, and proteins associated to the ...
Wieser, Heinz Gregor
core +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Epileptic Syndromes and Photosensitive Seizures
Pediatric Neurology Briefs, 2004 The clinical features of different types of photic-induced seizures and epileptic syndromes characterized by visual sensitivity are reviewed from the University of Pisa, Italy, and Centre St Paul, Marseille, France.
J Gordon Millichap
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A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies
Epilepsia Open, 2021 Objective Clinical care of rare and complex epilepsies is challenging, because evidence‐based treatment guidelines are scarce, the experience of many physicians is limited, and interdisciplinary treatment of comorbidities is required. The pathomechanisms
Tobias Baumgartner +39 more
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Brain Sciences, 2022 Objectives: Hemispherotomy (HT) is a surgical option for treatment of drug-resistant seizures due to hemispheric structural lesions. Factors affecting seizure outcome have not been fully clarified.
Chiara Pepi +9 more
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Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
Mother and daughter with adolescent-onset severe frontal lobe dysfunction and epilepsy
Dementia & NeuropsychologiaFamilial cases of early-onset prominent frontal lobe dysfunction associated with epilepsy have not been reported to date. We report a mother and her only daughter with incapacitating behavioral manifestations of frontal lobe dysfunction and epilepsy of ...
Giordani Rodrigues dos Passos +4 more
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Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy
Acta Epileptologica, 2023 Epilepsy is a neurological disease characterized by excessive and abnormal hyper-synchrony of electrical discharges of the brain and a predisposition to generate epileptic seizures resulting in a broad spectrum of neurobiological insults, imposing ...
John Agbo +5 more
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