Results 171 to 180 of about 117,712 (261)

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Efficacy and Safety of Adjunctive Perampanel in Young Children (7-46 Months) With Drug-Resistant Epilepsy: A Real-World Study. [PDF]

CNS Neurosci Ther
Zeng Q, Xia X, Zheng H, Yang L, Jiang L, Hu Y.   +5 more
europepmc   +1 more source

A novel biomimetic liposome drug delivery system mediated by macrophage targeting for precision treatment of encephalitis

BMEMat, EarlyView.
An advanced macrophage‐mediated biomimetic liposome (AC‐LP@RAW) that can penetrate the BBB and precisely target inflammatory sites in the deep brain was established in this study based on the unique immune homing property of macrophages, and showed a significantly improved delivery of curcumin to the brain.
Mengru Wu, Baoqin Song, Zhihao Chen, Wenzhong Li, Wanjun Liang, Xiu Wang   +5 more
wiley   +1 more source

Epilepsy Treatment Outcome and Associated Factors in Children and Adolescents in a Resource-limited Setting: A Retrospective Cohort Study. [PDF]

Clin Med Insights Pediatr
Shibeshi MS, Gari KT.
europepmc   +1 more source

Variations in Human Trigeminal and Facial Nerve Branches and Foramina Identified by Dissection and Microcomputed Tomography

Clinical Anatomy, EarlyView.
ABSTRACT The aim of this study was to identify branches of the trigeminal and facial nerves (FNs) relevant to surgical incisions and injections and the scalp block techniques in the frontotemporal region, and to determine their relationships with superficial vascular structures and bony landmarks.
Hannah L. Grimes, Valentina Pizzuti, Maria A. Wright, Kane P. J. Colston, Thomas Santarius, Susan Jones   +5 more
wiley   +1 more source

Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States. [PDF]

Epilepsia Open
Ostendorf AP, Eisner M, Abdel-Rasoul M, Ahrens SM, Twanow JD, Goodkin HP, Beatty CW.   +6 more
europepmc   +1 more source

Malposition of a Port Catheter in the Azygos Vein: Endovascular Repositioning Using a Long Loop Snare Technique

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Port catheters provide a reliable, long‐term venous access option in children for repeated administration of medications or parenteral nutrition. A cardiac catheterization procedure was performed in a 7‐year‐old girl in whom lateral chest radiography revealed posterior deviation suggestive of azygos vein malposition.
Axel Rentzsch, Annabelle Wagner, Jochen Pfeifer, Hashim Abdul‐Khaliq   +3 more
wiley   +1 more source

New insights from MRI-guided laser interstitial thermal therapy for refractory epilepsy: a state-of-the-art overview. [PDF]

Front Surg
Quispe-Vicuña C, Terry F, Cabanillas-Lazo M, Enríquez-Marulanda A, Pacheco-Barrios N, Yazdanian F, Zila-Velasque JP, Soriano-Moreno DR, Moran-Mariños C, Luther E, Daggubati L, Merenzon M, Lopez-Calle J, Burneo JG, Komotar RJ, Moses ZB, Rolston JD, Alva-Diaz C.   +17 more
europepmc   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Prognostic factors in vagus nerve stimulation for drug-resistant epilepsy. Results from a systematic review and meta-analysis of the literature. [PDF]

Neurosurg Rev
Martinelli R, Ciaffi G, Fuggetta F, D'Ercole M, Burattini B, Izzo A, Montano N.   +6 more
europepmc   +1 more source