Results 141 to 150 of about 733,442 (314)

Epilepsy – A Brief Overview [PDF]

, 2005
Epilepsy is a neurological condition in which an individual experiences chronic abnormal bursts of electrical discharge in the brain. These seizures can cause a variety symptoms depending on the areas of the brain affected. Symptoms can vary from mild to
Koyama, Alain
core  

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

, 2010
Jonathan O’Muircheartaigh, Christian Vollmar, Gareth J. Barker, Veena Kumari, Mark R. Symms, Pamela J. Thompson, John S. Duncan, Matthias J. Koepp, Mark P. Richardson   +8 more
openalex   +2 more sources

Unmet needs in patients with epilepsy, following audit, educational intervention and the introduction of the New General Practice Contract [PDF]

, 2011
I. Minshall, David F. Smith
openalex   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Minimizing AED Adverse Effects: Improving Quality of Life in the Interictal State in Epilepsy Care

, 2009
Erik K. St. Louis
openalex   +2 more sources

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

COVID‐19 response in a long‐term care facility for people with epilepsy

Epilepsia Open
Objective To assess asymptomatic rates and severity of SARS‐CoV‐2 infection in people with epilepsy and their healthcare workers in a long‐term care facility which had implemented weekly surveillance testing between April 2020 and June 2022.
Luisa Delazer, Noah Pressler, Simona Balestrini, Fenglai Xiao, Lisa M. Clayton, Jonny Anders‐Cannon, Rebecca Salvatierra, Ian Henry, Sanjay M. Sisodiya, Josemir W. Sander, Matthias J. Koepp   +10 more
doaj   +1 more source

Establishment of a transgene-free iPS cell line (SDCHi002-A) from a young patient bearing a NPRL3 mutation and suffering from Epilepsy

Stem Cell Research
Epilepsy affects ∼ 65 million people worldwide. In this study, peripheral blood mononuclear cells were isolated from a young patient patient bearing a Nitrogen Perntease Regulator Like 3 Protein (NPRL3) mutation and suffering from Epilepsy verified by ...
Song Su, Ying Ren, Hongwei Zhang, Yi Liu, Yong Liu, Zilong Li, Tong Zhang, Fang Fang   +7 more
doaj   +1 more source

Contralateral Motor Automatisms in Neocortical Temporal Lobe Epilepsy [PDF]

, 2004
Seyed M. Mirsattari, Donald H. Lee, Warren T. Blume   +2 more
openalex   +1 more source