Results 141 to 150 of about 384,910 (306)

Epilepsy surgery around language cortex [PDF]

, 2009
Background. Both epilepsy surgery and surgery close to functionally significant cortical areas have challenged neurosurgeons in the last two decades.
Ribenis, Aksels
core  

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Modulation of epileptogenesis through transplantation of human mesenchymal stem cells with or without GDNF release

Cellular and Molecular Life Sciences
Epilepsy is a central nervous system disorder causing uncontrollable seizures. One-third of patients do not respond to current medications, necessitating new treatments.
Eliška Waloschková, Esbjörn Melin, Camille Baumlin, My Andersson, Alberto Martínez Serrano, Merab Kokaia, Marco Ledri   +6 more
doaj   +1 more source

Localizable Fluorescent Metal Ion Indicators With Tunable Colors

Advanced Science, EarlyView.
A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self‐labeling proteins yields bright, color‐tunable potassium probes that permit wash‐free live‐cell imaging, revealing dynamic potassium efflux in stimulated neurons.
Ming‐Ming Wang, De‐en Sun, Klara Gries, Kai Johnsson   +3 more
wiley   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source

Epilepsy and Everyday Life Risks.

, 1997
Despite its favorable outcome in up to 90% of patients, epilepsy is still considered to carry a higher than normal risk of morbidity and accidents. Knowledge of the everyday life risks (illnesses, accidents) in patients with epilepsy is mostly anecdotal.
SPECCHIO, LUIGI MARIA, Beghi E, Cornaggia C. for the Risk in Epilepsy Study Group, .   +3 more
core  

Kids' perception about epilepsy

, 2015
Purpose. Epilepsy remains a stigmatized condition. Lack of information has been pointed to as a cause of the perpetuation of stigma. Our goal was to survey children's perception of epilepsy. Methods.
Fernandes, PT, Araujo, U, Noronha, ALA, Cabral, P, Li, LM   +4 more
core   +1 more source

Stiripentol for the treatment of refractory status epilepticus

Neurological Research and Practice
Background Status epilepticus (SE) is one of the most common neurological emergencies and an acutely life-threatening condition characterized by high mortality and morbidity.
Leona Möller, Ole J. Simon, Clara Jünemann, Meike Austermann-Menche, Marc-Philipp Bergmann, Lena Habermehl, Katja Menzler, Lars Timmermann, Adam Strzelczyk, Susanne Knake   +9 more
doaj   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

An Energy Autonomous Microneedle Array‐Based Sensing System for Continuous Biomarker Monitoring

Advanced Science, EarlyView.
This work presents an innovative self‐powered wearable biosensor system for real‐time monitoring of multiple biomarkers in interstitial fluid. The device integrates stainless steel‐based minimally invasive microneedles with ion‐selective membranes, enabling simultaneous Na+, K+, Ca2+, pH, and glucose detection.
Arnab Pal, Kai‐Po Fan, Sheng‐Chun Hung, Jaba Roy Chowdhury, Jun‐Hsun Chung, Meenakshi Ray, Hsiang‐Yun Hsu, Fu‐Cheng Kao, Kuei‐Lin Liu, Zong‐Hong Lin   +9 more
wiley   +1 more source