Results 181 to 190 of about 671,361 (363)
Advanced Science, EarlyView.The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge +16 more
wiley +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Advanced Science, EarlyView.The study develops a H•/H– transfer strategy enabling efficient hydrocyclization/defluorination of CF3‐acrylamides to synthesize Seletracetam derivatives with gem‐difluoroalkenes. Mechanistic studies reveal distinct pathways: the NiII‐H/PhSiH3 system operates through a hydrogen atom transfer process, while the 1,4‐Michael addition of H– appears to be ...
Yanjun Wan, Ronghui Shao, Jack R. Norton
wiley +1 more source
COVID‐19 response in a long‐term care facility for people with epilepsy
Epilepsia OpenObjective To assess asymptomatic rates and severity of SARS‐CoV‐2 infection in people with epilepsy and their healthcare workers in a long‐term care facility which had implemented weekly surveillance testing between April 2020 and June 2022.
Luisa Delazer +10 more
doaj +1 more source
Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
Advanced Science, EarlyView.This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang +6 more
wiley +1 more source
Cases of Palpitation of the Heart Due to Epilepsy, with Remarks [PDF]
, 1875 Wm. L. Lane
openalex +1 more source