Results 111 to 120 of about 88,260 (305)

The spatio-temporal mapping of epileptic networks: Combination of EEG–fMRI and EEG source imaging

, 2009
Simultaneous EEG–fMRI acquisitions in patients with epilepsy often reveal distributed patterns of Blood Oxygen Level Dependant (BOLD) change correlated with epileptiform discharges.
Lemieux, L., Lhatoo, S., Guye, M., L Lemieux, M Guye, McEvoy, A.W., Thornton, R., R Thornton, Michel, Christoph, Spinelli, L., Duncan, J.S., Michel, C.M., Spinelli, Laurent Jean-François, Carmichael, D.W., L Spinelli, C M Michel, R Rodionov, Rodionov, R., J S Duncan, Vulliemoz, Serge, Carmichael, D. W., S Vulliemoz, McEvoy, A. W., A W Mcevoy, Prof Louis Lemieux, Chesham Lane, Vulliemoz, S., D W Carmichael, S Lhatoo, Duncan, J. S.   +29 more
core   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

The Association of Epileptic Seizures after Acute Ischemic Stroke with Cerebral Cortical Involvement and Electroencephalographic Changes

Medicina
Background and objectives: while acute ischemic stroke is the leading cause of epilepsy in the elderly population, data about its risk factors have been conflicting.
Agnė Šmigelskytė, Gabija Rimkuvienė, Dominyka Žukaitė, Gerta Repečkaitė, Giedrė Jurkevičienė   +4 more
doaj   +1 more source

Clinical and Neurophysiological features of different forms of epileptic falls

, 1997
Falling seizures are a heterogeneous group of epileptic seizures in which the fail represents the main or only clinical manifestation. In this chapter, we discuss the clinical and neurophysiological characteristics of focal atonic epileptic events, such ...
R. Michelucci, R. Rizzi, E. Gardella, MELETTI, Stefano, G. Rubboli, F. Valzania, L. Parmeggiani, C. A. Tassinari, A. Zaniboni   +8 more
core  

Seizures in the prehospital setting

, 2010
Seizures are a common occurrence in the prehospital arena, however, with numerous conditions causing seizures, prehospital clinicians can be left with a dilemma in the treatment of these patients. Patients who are actively seizing will predominately have
Cashmore, Jamie
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Regulation of emotions in individuals experiencing psychogenic non-epileptic seizures [PDF]

, 2013
Despite the long history of psychogenic non-epileptic seizures (PNES), relatively little is known about the mechanisms that cause and maintain this condition.
Urbanek, M.
core  

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source