Results 131 to 140 of about 8,267 (258)

A new perspective on drug‐resistant epilepsy in children with focal cortical dysplasia type 1: From challenge to favorable outcome

open access: yesEpilepsia, Volume 66, Issue 3, Page 632-647, March 2025.
Abstract Objective We comprehensively characterized a large pediatric cohort with focal cortical dysplasia (FCD) type 1 to expand the phenotypic spectrum and to identify predictors of postsurgical outcomes. Methods We included pediatric patients with histopathological diagnosis of isolated FCD type 1 and at least 1 year of postsurgical follow‐up.
Barbora Splitkova   +18 more
wiley   +1 more source

Incidence of childhood and youth epilepsy: A population‐based prospective cohort study utilizing current International League Against Epilepsy classifications for seizures, syndromes, and etiologies

open access: yesEpilepsia, Volume 66, Issue 3, Page 776-789, March 2025.
Abstract Objective This study was undertaken to describe incidence and distribution of seizures, etiologies, and epilepsy syndromes in the general child and youth population, using the current International League Against Epilepsy (ILAE) classifications. Methods The study platform is the Norwegian Mother, Father, and Child Cohort Study (MoBa). Epilepsy
Truls Vikin   +4 more
wiley   +1 more source

Long‐term efficacy and safety of cannabidiol in patients with treatment‐resistant focal epilepsies treated in the Expanded Access Program

open access: yesEpilepsia, EarlyView.
Open‐label CBD treatment was associated with sustained seizure reduction through 144 weeks, with a consistent safety profile in patients with treatment‐resistant focal epilepsies, regardless of epilepsy type. Abstract Objective Cannabidiol (CBD) treatment was associated with long‐term seizure reduction in patients with various treatment‐resistant ...
Anup D. Patel   +8 more
wiley   +1 more source

Study of the Effects of Mogadon in Treatment of Infantile Spasms

open access: yesپزشکی بالینی ابن سینا, 2001
Among epileptic syndromes the infantile spasms ( west syndrome ) is the    most  malignant one and leads to  irreparable brain damage, which is    related directly to duration of spasms.
Mohammad Mahdi Taghdiri
doaj  

Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations

open access: yesEpilepsia, EarlyView.
Abstract Epilepsy is a chronic neurological condition marked by recurrent, uncontrolled seizures. Identifying comorbidities in epilepsy is critical for preventing mortality. Among these, the autonomic nervous system's role in epilepsy often manifests as cardiac disorders. Patients with epilepsy (PWE), particularly those with poorly controlled seizures,
Enes Akyuz   +2 more
wiley   +1 more source

What defines response to vagus nerve stimulation in children with drug‐resistant epilepsy? A prospective cohort study from the CONNECTiVOS collaboration

open access: yesEpilepsia, EarlyView.
Abstract Objectives Responsiveness to vagus nerve stimulation (VNS) in children with drug‐resistant epilepsy (DRE) is often defined based on reduction in seizure frequency, typically at the 50% threshold, with limited consideration to the effects of therapy on seizure severity and health‐related quality of life (HRQoL). In the current report, we sought
Farbod Niazi   +38 more
wiley   +1 more source

Cannabidiol attenuates epileptic phenotype and increases survival in a mouse model of developmental and epileptic encephalopathy type 1

open access: yesEpilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathy type 1 (DEE1) is a rare drug‐resistant pediatric epilepsy caused by trinucleotide repeat expansions in the X‐linked ARX gene, leading to elongation of the first polyalanine tract. It presents with early onset tonic seizures or spasms, developmental and cognition delay, and high risk of ...
Lucia Verrillo   +9 more
wiley   +1 more source

Magnetoencephalography Reveals a Unique Neurophysiological Profile of Focal-Onset Epileptic Spasms

open access: bronze, 2013
Yosuke Kakisaka   +8 more
openalex   +2 more sources

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