Results 31 to 40 of about 63,715 (255)

Short-term outcome of intravenous methylprednisolone pulse therapy versus oral prednisolone in patients with epileptic spasms

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background Infantile spasm (IS) is an age-specific epileptic disorder of early infancy that typically presents with epileptic spasms occurring in clusters.
Abdelsattar Abdullah Elsayeh, Mohammad Ali Saeed Hassan   +1 more
doaj   +1 more source

Long-term developmental outcome in infantile epileptic spasms syndrome after high-dose prednisolone and vigabatrin treatment. [PDF]

Epilepsia Open
Abstract Objective To evaluate long‐term developmental outcomes and identify independent predictors of favorable developmental outcomes at 3 years of age in children with infantile epileptic spasms syndrome (IESS) treated with a standardized stepwise vigabatrin and high‐dose prednisolone protocol.
Jang S, Shin HJ, Kim SH, Lee JS, Ko A, Kang HC.   +5 more
europepmc   +2 more sources

Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants

Arquivos de Neuro-Psiquiatria, 2023
Background Infantile epileptic spasms syndrome (IESS) is a rare but severe condition affecting children early and is usually secondary to an identifiable brain disorder.
Letícia Pereira de Brito Sampaio, Adélia Maria de Miranda Henriques-Souza, Mariana Ribeiro Marcondes da Silveira, Lisiane Seguti, Mara Lúcia Schmitz Ferreira Santos, Maria Augusta Montenegro, Sérgio Antoniuk, Maria Luíza Giraldes de Manreza   +7 more
doaj   +1 more source

Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21

Neurobiology of Disease, 2023
Children with Down syndrome (DS, trisomy of chromosome 21) have an increased risk of infantile spasms (IS). As an epileptic encephalopathy, IS may further impair cognitive function and exacerbate neurodevelopmental delays already present in children with
Li-Rong Shao, Feng Gao, Viveka Chinnasamy, Yasuhiro Kazuki, Mistuo Oshimura, Roger H. Reeves, Carl E. Stafstrom   +6 more
doaj   +1 more source

Unilobar surgery for symptomatic epileptic spasms

Annals of Clinical and Translational Neurology, 2016
AbstractObjectiveTo assess factors associated with favorable seizure outcome after surgery for symptomatic epileptic spasms and improve knowledge on pathophysiology of this seizure type.MethodsInclusion criteria were: (1) age between 6 months and 15 years at surgery; (2) active epileptic spasms; (3) follow‐up after surgery >1 year.ResultsWe ...
Barba, Carmen, Mai, Roberto, Grisotto, Laura, Gozzo, Francesca, Pellacani, Simona, Tassi, Laura, Francione, Stefano, Giordano, Flavio, Cardinale, Francesco, GUERRINI, RENZO   +9 more
openaire   +3 more sources

Association mapping of genomic microdeletions and common susceptibility variants predisposing to genetic generalized epilepsies [PDF]

, 2013
Approximately 3% of the general population is affected by epilepsy during lifetime, making epilepsy one of the most common neurological diseases. Genetic generalized epilepsies (GGE) are the most common of genetic epilepsies and account for 20-30% of ...
Trucks, Holger Sebastian
core   +1 more source

Atypical presentation in Rasmussen encephalitis: delayed late-onset periodic epileptic spasms

, 2011
A five-and-a-half-year-old girl started experiencing progressive left hemiparesis at age two and a half years. At age five years and four months she started presenting clusters of asymmetric periodic epileptic spasms with no hypsarrhythmia. the ictal EEG
Caboclo, Luis Otavio Sales Ferreira [UNIFESP], Scattolin, Monica [UNIFESP], Yacubian, Elza Márcia Targas [UNIFESP], Zaninotto, Ana Luiza [UNIFESP], Hamad, Ana Paula Andrade [UNIFESP], Lancellotti, Carmem Lucia Penteado, Ferrari, Taissa Pinheiro Fernandes [UNIFESP], Carrete Junior, Henrique [UNIFESP], Centeno, Ricardo Silva [UNIFESP]   +8 more
core   +1 more source

Epileptic spasms are a feature of DEPDC5 mTORopathy [PDF]

, 2015
OBJECTIVE: To assess the presence of DEPDC5 mutations in a cohort of patients with epileptic spasms. METHODS: We performed DEPDC5 resequencing in 130 patients with spasms, segregation analysis of variants of interest, and detailed clinical assessment of ...
Harvey, AS, Howell, KB, Berkovic, SF, Mefford, HC, Mullen, SA, Regan, BM, Scheffer, IE, Zemel, M, Crompton, DE, Carvill, GL, Schneider, AL, Sullivan, J, Mandelstam, S, Dibbens, L, McMahon, JM, Leventer, RJ, Saykally, J   +16 more
core   +1 more source

Treatment of Symptomatic Infantile Spasms

Pediatric Neurology Briefs, 2013
Investigators at Tokyo Women's Medical University studied the clinical, radiological, and EEG characteristics of 69 patients with infantile spasms (IS) followed for 3-74 months (mean 18 months) after initial cessation of epileptic spasms (ES).
J Gordon Millichap
doaj   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source