Results 21 to 30 of about 8,257 (246)

Case report: De novo variant of SETD1A causes infantile epileptic spasms syndrome

Frontiers in Neurology, 2023
Infantile epileptic spasms syndrome (IESS) is one of the most common epileptic encephalopathies of infancy, with typical clinical features defined by a triad of epileptic spasms, hypsarrhythmia, and developmental delay.
Mingping Lan, Yanjuan Wang, Sixiu Li, Lili Zhao, Ping Liu, Wenguang Hu   +5 more
doaj   +1 more source

Infantile Spasms in Remission May Reemerge as Intractable Epileptic Spasms [PDF]

Epilepsia, 2003
Summary: Background:West syndrome consists of infantile spasms with hypsarrhythmia and is perceived as a disorder of infants.Methods:We describe 10 patients with West syndrome with spasms that remitted, started again, and persisted (followed up for 8–25 years).Results:In all, West syndrome developed at younger than 17 months (five cryptogenic, six ...
Peter, Camfield, Carol, Camfield, Anne, Lortie, Husam, Darwish   +3 more
openaire   +2 more sources

A conundrum of West syndrome, behavioural problems and parental expressed emotions: a case report

General Psychiatry, 2020
West syndrome (WS) is the most common epileptic syndrome in infancy characterised by epileptic spasms, hypsarrhythmia and neurodevelopmental problems. Epileptic spasms remain in many ways a conundrum, and the ideal intervention, as well as how to screen ...
Yogender Kumar Malik, Nidhi Chauhan, Akhilesh Sharma, Susanta Padhy   +3 more
doaj   +1 more source

Short-term outcome of intravenous methylprednisolone pulse therapy versus oral prednisolone in patients with epileptic spasms

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background Infantile spasm (IS) is an age-specific epileptic disorder of early infancy that typically presents with epileptic spasms occurring in clusters.
Abdelsattar Abdullah Elsayeh, Mohammad Ali Saeed Hassan   +1 more
doaj   +1 more source

Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants

Arquivos de Neuro-Psiquiatria, 2023
Background Infantile epileptic spasms syndrome (IESS) is a rare but severe condition affecting children early and is usually secondary to an identifiable brain disorder.
Letícia Pereira de Brito Sampaio, Adélia Maria de Miranda Henriques-Souza, Mariana Ribeiro Marcondes da Silveira, Lisiane Seguti, Mara Lúcia Schmitz Ferreira Santos, Maria Augusta Montenegro, Sérgio Antoniuk, Maria Luíza Giraldes de Manreza   +7 more
doaj   +1 more source

Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21

Neurobiology of Disease, 2023
Children with Down syndrome (DS, trisomy of chromosome 21) have an increased risk of infantile spasms (IS). As an epileptic encephalopathy, IS may further impair cognitive function and exacerbate neurodevelopmental delays already present in children with
Li-Rong Shao, Feng Gao, Viveka Chinnasamy, Yasuhiro Kazuki, Mistuo Oshimura, Roger H. Reeves, Carl E. Stafstrom   +6 more
doaj   +1 more source

Unilobar surgery for symptomatic epileptic spasms

Annals of Clinical and Translational Neurology, 2016
AbstractObjectiveTo assess factors associated with favorable seizure outcome after surgery for symptomatic epileptic spasms and improve knowledge on pathophysiology of this seizure type.MethodsInclusion criteria were: (1) age between 6 months and 15 years at surgery; (2) active epileptic spasms; (3) follow‐up after surgery >1 year.ResultsWe ...
Barba, Carmen, Mai, Roberto, Grisotto, Laura, Gozzo, Francesca, Pellacani, Simona, Tassi, Laura, Francione, Stefano, Giordano, Flavio, Cardinale, Francesco, GUERRINI, RENZO   +9 more
openaire   +3 more sources

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open
Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
doaj   +2 more sources

Treatment of Symptomatic Infantile Spasms

Pediatric Neurology Briefs, 2013
Investigators at Tokyo Women's Medical University studied the clinical, radiological, and EEG characteristics of 69 patients with infantile spasms (IS) followed for 3-74 months (mean 18 months) after initial cessation of epileptic spasms (ES).
J Gordon Millichap
doaj   +1 more source

Epileptic Spasms and Partial Seizures Associated with Vitamin B12 Deficiency: Case Report and Literature Review

Archives of Epilepsy, 2017
Epileptic spasms associated with vitamin B12 deficiency are rare. Epileptic spasms in addition to partial seizures due to vitamin B12 deficiency have never been reported in the literature. A 3½-month-old girl presented to clinic with partial seizures and
Uğur IŞIK, Sonay BEYATLI
doaj   +1 more source