Results 201 to 210 of about 2,272,583 (371)

A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES joint translational task force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski, Julika Pitsch, Aristea S. Galanopoulou, Rüdiger Köhling   +3 more
wiley   +1 more source

Does deep brain stimulation of the anterior nucleus of the thalamus represent the future of Lennox-Gastaut syndrome? [PDF]

J Neurol
Poulen G, Gélisse P, Crespel A, Chan-Seng E, Moser PO, Coubes P.   +5 more
europepmc   +1 more source

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

Annals of Neurology, EarlyView.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino, Audrey G. O'Neill, Justin M. Kollman, Hyder A. Jinnah, Michael Zech   +4 more
wiley   +1 more source

Predictive model for initial response to first-line treatment in children with infantile epileptic spasms syndrome. [PDF]

Ital J Pediatr
Ge W, Wan L, Wang Z, Fu L, Yang G.
europepmc   +1 more source

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska, Andre G. Skirtach, Anna M. Kaczmarek   +2 more
wiley   +1 more source

Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21. [PDF]

Front Pediatr
Chen H, Numis AL, Shellhaas RA, Mytinger JR, Samanta D, Singh RK, Hussain SA, Takacs D, Knupp KG, Shao LR, Stafstrom CE.   +10 more
europepmc   +1 more source

A novel germline PIGA mutation in Ferro‐Cerebro‐Cutaneous syndrome: A neurodegenerative X‐linked epileptic encephalopathy with systemic iron‐overload [PDF]

, 2013
Kathryn J. Swoboda, Rebecca L. Margraf, John C. Carey, Holly Zhou, Tara Newcomb, Emily Coonrod, Jacob Durtschi, Kalyan C. Mallempati, Attila Kumánovics, Ben E. Katz, Karl V. Voelkerding, John M. Opitz   +11 more
openalex   +1 more source

Merritt-Putnam Symposium | Developmental and Epileptic Encephalopathies-Current Concepts and Novel Approaches. [PDF]

Epilepsy Curr
Scott RC, Hsieh J, McTague A, Mahoney JM, Christian-Hinman CA.   +4 more
europepmc   +1 more source

Case Report: White-Sutton syndrome and cannabidiol, an update on a reported patient with a successful response to off--label therapy. [PDF]

Front Pediatr
Perilli L, Carbone S, Minerva M, Rossi MM, Curcio MR, Lotti F, Grosso S.   +6 more
europepmc   +1 more source

Lennox‐Gastaut syndrome may be a curable, reversible epileptic encephalopathy [PDF]

, 2015
Yu‐Tze Ng, Sandipan Pati, Jessica R. Fesler   +2 more
openalex   +1 more source