The Concept of Drug-Resistant Epileptogenic Zone [PDF]
Frontiers in Neurology, 2019 Resective surgery is the most effective way to treat drug-resistant epilepsy. Despite extensive pre-surgical evaluation, only 30–70% patients would become seizure-free after surgery.
Chunbo Zhang, Patrick Kwan, Patrick Kwan
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Localizing the Epileptogenic Zone with Novel Biomarkers. [PDF]
Semin Pediatr Neurol, 2021 Several noninvasive methods, such as high-density EEG or magnetoencephalography, are currently used to delineate the epileptogenic zone (EZ) during the presurgical evaluation of patients with drug resistant epilepsy (DRE). Yet, none of these methods can reliably identify the EZ by their own. In most cases a multimodal approach is needed.
Papadelis C, Perry MS.
europepmc +3 more sources
Non-Invasive Localization of Epileptogenic Zone in Drug-Resistant Epilepsy Based on Time–Frequency Analysis and VGG Convolutional Neural Network [PDF]
BioengineeringThe mainstream method for treating drug-resistant epilepsy (DRE) is surgical resection of the epileptogenic zone. Non-invasive automatic localization of epileptogenic zone can be used to guide electrode implantation and improve the effectiveness and ...
Yaqing Liu, Yalin Wang, Tiancheng Wang
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Voxel‐based and surface‐based cortical morphometric MRI applications for identifying the epileptogenic zone: A narrative review [PDF]
Epilepsia OpenApproximately 40% of patients with drug‐resistant epilepsy referred for surgical evaluation have no epileptogenic lesion on MRI (MRI‐negative). MRI‐negative epilepsy is associated with poorer seizure freedom prognosis and has therefore motivated the ...
Jacob Bunyamin +5 more
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Time-Varying Networks of Inter-Ictal Discharging Reveal Epileptogenic Zone [PDF]
Frontiers in Computational Neuroscience, 2017 The neuronal synchronous discharging may cause an epileptic seizure. Currently, most of the studies conducted to investigate the mechanism of epilepsy are based on EEGs or functional magnetic resonance imaging (fMRI) recorded during the ictal discharging
Luyan Zhang +14 more
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Evaluating the Efficacy of CortexID Quantitative Analysis in Localization of the Epileptogenic Zone in Patients with Temporal Lobe Epilepsy [PDF]
Neurology and TherapyIntroduction There remains a critical need for precise localization of the epileptogenic foci in individuals with drug-resistant epilepsy (DRE). 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) imaging can reveal hypometabolic regions during
Shuangshuang Li +10 more
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Epileptogenic zone-targeting nanoparticle drug delivery system for antiseizure medication [PDF]
Materials Today BioEpilepsy is a chronic neurological disorder affecting over 65 million people worldwide, characterized by abnormal excessive excitation of neuronal networks.
Honglu Ping +6 more
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Localization of the Epileptogenic Zone Using High Frequency Oscillations [PDF]
Frontiers in Neurology, 2019 For patients with drug-resistant focal epilepsy, surgery is the therapy of choice in order to achieve seizure freedom. Epilepsy surgery foremost requires the identification of the epileptogenic zone (EZ), defined as the brain area indispensable for ...
Aljoscha Thomschewski +3 more
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Structural connectivity changes in focal epilepsy: Beyond the epileptogenic zone. [PDF]
EpilepsiaAbstractObjectiveEpilepsy is recognized increasingly as a network disease, with changes extending beyond the epileptogenic zone (EZ). However, more studies of structural connectivity are needed to better understand the behavior and nature of this condition.MethodsIn this study, we applied differential tractography, a novel technique that measures ...
Barrios-Martinez JV +11 more
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Localization of Epileptogenic Zone With the Correction of Pathological Networks [PDF]
Frontiers in Neurology, 2018 Patients with focal drug-resistant epilepsy are potential candidates for surgery. Stereo-electroencephalograph (SEEG) is often considered as the “gold standard” to identify the epileptogenic zone (EZ) that accounts for the onset and propagation of ...
Chuanzuo Yang +10 more
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