Results 41 to 50 of about 12,577 (248)

A fingerprint of the epileptogenic zone in human epilepsies [PDF]

Brain, 2017
Defining a bio-electrical marker for the brain area responsible for initiating a seizure remains an unsolved problem. Fast gamma activity has been identified as the most specific marker for seizure onset, but conflicting results have been reported. In this study, we describe an alternative marker, based on an objective description of interictal to ...
Grinenko, Olesya, Li, Jian, Mosher, John C, Wang, Irene Z, Bulacio, Juan C, Gonzalez-Martinez, Jorge, Nair, Dileep, Najm, Imad, Leahy, Richard M, Chauvel, Patrick   +9 more
openaire   +2 more sources

Second‐hit DEPDC5 mutation is limited to dysmorphic neurons in cortical dysplasia type IIA

Annals of Clinical and Translational Neurology, 2019
Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy and is associated with pathogenic variants in mTOR pathway genes. How germline variants cause these focal lesions is unclear, however a germline + somatic “2‐hit” model is hypothesized.
Wei Shern Lee, Sarah E. M. Stephenson, Katherine B. Howell, Kate Pope, Greta Gillies, Alison Wray, Wirginia Maixner, Simone A. Mandelstam, Samuel F. Berkovic, Ingrid E. Scheffer, Duncan MacGregor, Anthony Simon Harvey, Paul J. Lockhart, Richard J. Leventer   +13 more
doaj   +1 more source

Mapping the epileptic brain with EEG dynamical connectivity: established methods and novel approaches [PDF]

, 2012
Several algorithms rooted in statistical physics, mathematics and machine learning are used to analyze neuroimaging data from patients suffering from epilepsy, with the main goals of localizing the brain region where the seizure originates from and of ...
Boon, Paul, Marinazzo, Daniele, Papadopoulou, Margarita, Vonck, Kristl   +3 more
core   +1 more source

Multimodal quantitative magnetic resonance imaging analysis with individualized postprocessing in patients with drug-resistant focal epilepsy and conventional visual inspection negative for epileptogenic lesions

Clinics
OBJECTIVES: Approximately one-third of candidates for epilepsy surgery have no visible abnormalities on conventional magnetic resonance imaging. This is extremely discouraging, as these patients have a less favorable prognosis.
Lucas Giansante Abud, Tonicarlo Rodrigues Velasco, Carlos Ernesto Garrido Salmon, Americo Ceiki Sakamoto, Thiago Giansante Abud, Rodrigo Antonio Pessini, Daniel Giansante Abud, João Pereira Leite, Antonio Carlos dos Santos   +8 more
doaj   +1 more source

Designer receptor technology for the treatment of epilepsy

EBioMedicine, 2019
Epilepsy remains refractory to medical treatment in ~30% of patients despite decades of new drug development. Neurosurgery to remove or disconnect the seizure focus is often curative but frequently contraindicated by risks of irreversible impairment to ...
Andreas Lieb, Mikail Weston, Dimitri M. Kullmann   +2 more
doaj   +1 more source

Development of invasive EEG in epilepsy surgery (review)

Сибирский научный медицинский журнал, 2020
There are different diagnostic methods that used for localization of the seizure onset zone in focal refractory epilepsy cases. Invasive video-EEG recording is the «gold standard» in determining the epileptogenic zone among other diagnostic methods ...
V. M. Dzhafarov, J. A. Rzaev
doaj   +1 more source

Ictal verbal help-seeking: Occurrence and the underlying etiology. [PDF]

, 2016
PURPOSE: Ictal verbal help-seeking has never been systematically studied before. In this study, we evaluated a series of patients with ictal verbal help-seeking to characterize its frequency and underlying etiology.
Aminian, Narsis, Asadi-Pooya, Ali Akbar, Asadollahi, Marjan, Bujarski, Krzysztof, Rabiei, Amin H., Sperling, Michael R., Wyeth, Dale   +6 more
core   +2 more sources

A New Approach to Automated Epileptic Diagnosis Using EEG and Probabilistic Neural Network

, 2008
Epilepsy is one of the most common neurological disorders that greatly impair patient' daily lives. Traditional epileptic diagnosis relies on tedious visual screening by neurologists from lengthy EEG recording that requires the presence of seizure (ictal)
Bao, Forrest Sheng, Lie, Donald Yu-Chun, Zhang, Yuanlin   +2 more
core   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

HIGH-FREQUENCY ELECTROCORTICOGRAPHIC MARKER OF EPILEPTOGENIC ZONE

Translational Medicine, 2019
Background. The search for new markers of the epileptogenic zone (EZ) for the surgical treatment of epilepsy is currently of relevance. Pathological high-frequency oscillations (pHFO) are considered to be a potential marker for EZ. Papers devoted to this topic are few and insufficiently systematized, mostly due to a small quantity of patients.Objective.
N. B. Arkhipova, A. Yu. Ulitin, M. M. Tastanbekov, M. V. Aleksandrov   +3 more
openaire   +2 more sources