Results 151 to 160 of about 2,663,291 (229)

Correction: From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis

PLoS Genetics, 2008
Table 1b is not displayed correctly in the published article. Please see the correct Table 1 here:
David L. Aylor, Zhao-Bang Zeng
openaire   +4 more sources

WISH-R– a fast and efficient tool for construction of epistatic networks for complex traits and diseases

BMC Bioinformatics, 2018
Background Genetic epistasis is an often-overlooked area in the study of the genomics of complex traits. Genome-wide association studies are a useful tool for revealing potential causal genetic variants, but in this context, epistasis is generally ...
Victor A. O. Carmelo, Lisette J. A. Kogelman, Majbritt Busk Madsen, Haja N. Kadarmideen   +3 more
doaj   +1 more source

Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]

, 2004
Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K., Ellenberger, E. A., Mueller, Janet L., Quock, Raymond M., Vaughn, Linda K.   +4 more
core   +1 more source

Does replication groups scoring reduce false positive rate in SNP interaction discovery? [PDF]

, 2010
BACKGROUNG. Computational methods that infer single nucleotide polymorphism (SNP) interactions from phenotype data may uncover new biological mechanisms in non-Mendelian diseases. However, practical aspects of such analysis face many problems.
Curk, Tomaz, Demsar, Janez, Toplak, Marko, Zupan, Blaz   +3 more
core  

Distributed transformer for high order epistasis detection in large-scale datasets

Scientific Reports
Understanding the genetic basis of complex diseases is one of the most important challenges in current precision medicine. To this end, Genome-Wide Association Studies aim to correlate Single Nucleotide Polymorphisms (SNPs) to the presence or absence of ...
Miguel Graça, Ricardo Nobre, Leonel Sousa, Aleksandar Ilic   +3 more
doaj   +1 more source

Reducing Epistasis and Pleiotropy Can Avoid the Survival of the Flattest Tragedy

Biology
This study investigates whether reducing epistasis and pleiotropy enhances mutational robustness in evolutionary adaptation, utilizing an indirect encoded model within the “survival of the flattest” (SoF) fitness landscape.
Priyanka Mehra, Arend Hintze
doaj   +1 more source

THE EFFECT OF EPISTASIS AND GAMETIC UNBALANCE ON GENETIC LOAD [PDF]

Genetics, 1966
S. K. Jain, R. W. Allard, P. E. Hansche
openaire   +3 more sources

UEG Week 2025 Moderated Posters

United European Gastroenterology Journal, Volume 13, Issue S8, Page S189-S802, October 2025.
wiley   +1 more source

Partnering Strategies for Fitness Evaluation in a Pyramidal Evolutionary Algorithm

, 2008
This paper combines the idea of a hierarchical distributed genetic algorithm with different inter-agent partnering strategies. Cascading clusters of sub-populations are built from bottom up, with higher-level sub-populations optimising larger parts of ...
Aickelin, Uwe, Bull, Larry
core  

Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness. [PDF]

Genetics
Goldstein I, Hale JJ, Ehrenreich IM.
europepmc   +1 more source