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A mathematical framework for the quantitative analysis of genetic buffering. [PDF]
PLoS GenetKaragiannis J.
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A Thermodynamic Cycle to Predict the Competitive Inhibition Outcomes of an Evolving Enzyme. [PDF]
J Chem Theory ComputCetin E +3 more
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Negative epistasis limits current codon optimization approaches
Gees M +4 more
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Variations and predictability of epistasis on an intragenic fitness landscape
Baheti S, Raj N, Saini S.
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W-Test for Genetic Epistasis Testing
2021The genetic epistasis effect has been widely acknowledged as an essential contributor to genetic variation in complex diseases. In this chapter, we introduce a powerful and efficient statistical method, called W-test, for genetic epistasis testing.
Rui Sun, Haoyi Weng, Maggie Haitian Wang
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The Causes and Consequences of Genetic Interactions (Epistasis)
Annual Review of Genomics and Human Genetics, 2019The same mutation can have different effects in different individuals. One important reason for this is that the outcome of a mutation can depend on the genetic context in which it occurs. This dependency is known as epistasis. In recent years, there has been a concerted effort to quantify the extent of pairwise and higher-order genetic interactions ...
Ben Lehner +3 more
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On the Partitioning of Genetic Variance with Epistasis
2014The decomposition of genetic variance into additive, dominance, and epistatic components is a common procedure in quantitative genetics. Yet, the interpretation of this variance partition is not trivial, especially concerning nonadditive components.
José M. Álvarez-Castro +2 more
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