Results 181 to 190 of about 50,815 (199)
Interactions with polygenic background impact quantitative traits in the UK Biobank
Ferreira LAF, Hu S, Davies RW, Myers SR.
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Epistatic contributions to human traits via transcription factor mechanisms
Roskams-Hieter B +6 more
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W-Test for Genetic Epistasis Testing
2021The genetic epistasis effect has been widely acknowledged as an essential contributor to genetic variation in complex diseases. In this chapter, we introduce a powerful and efficient statistical method, called W-test, for genetic epistasis testing.
Rui, Sun +2 more
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Detecting genetic epistasis by differential departure from independence
Molecular Genetics and Genomics, 2022Countering prior beliefs that epistasis is rare, genomics advancements suggest the other way. Current practice often filters out genomic loci with low variant counts before detecting epistasis. We argue that this practice is far from optimal because it can throw away strong epistatic patterns.
Ruby Sharma +3 more
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Epistasis and genetic pathways
2020This chapter explains epistasis, whereby the phenotype of one gene masks the phenotype of a different gene, and describes how it can be exploited to construct the logical pathway of the gene interactions that underlie a biological process. It notes that every biological process is the outcome of genes or gene products working together in pathways and ...
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Epistasis in genetic algorithms revisited
Information Sciences, 1997Abstract Davidor epistasis is first analyzed to give its meaning a better understanding. Then, a generalization is introduced to investigate interactions between one or more positions on a chromosome, allowing a more accurate analysis of fitness landscape.
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On the Partitioning of Genetic Variance with Epistasis
2014The decomposition of genetic variance into additive, dominance, and epistatic components is a common procedure in quantitative genetics. Yet, the interpretation of this variance partition is not trivial, especially concerning nonadditive components.
José M, Alvarez-Castro +1 more
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The Causes and Consequences of Genetic Interactions (Epistasis)
Annual Review of Genomics and Human Genetics, 2019The same mutation can have different effects in different individuals. One important reason for this is that the outcome of a mutation can depend on the genetic context in which it occurs. This dependency is known as epistasis. In recent years, there has been a concerted effort to quantify the extent of pairwise and higher-order genetic interactions ...
Júlia, Domingo +2 more
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Genetic interactions : epistasis, linkage and speciation
2019Population genetics often makes simplifying assumptions regarding the interactions between genes. Interactions between genes, whether through epistasis or linkage effects, vastly increase the complexity of mathematical modeling, and often require data that has not historically been available. In this Dissertation, I present three chapters that use this
Dagilis, Andrius Jonas +1 more
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