Results 141 to 150 of about 132,877 (191)

Liquid Crystalline Networks Hamper the Malignancy of Cancer Cells

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Liquid Crystalline Networks are used as scaffolds for the growth of A375 melanoma cells demonstrating to affect their malignancy. Indeed, only by contact, these materials reduces cell proliferation and colony formation capacity, while increasing the number of senescent cells and promoting the mesenchymal to epithelial transition.
Daniele Martella, Ignazia Tusa, Alessandro Tubita, Alessia Negri, Marco Turriani, Marta Rojas‐Rodríguez, Martina Salzano de Luna, Alessio Menconi, Camilla Parmeggiani, Elisabetta Rovida   +9 more
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases

Advanced Materials, EarlyView.
This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu, Rockie Haiyao Ding, Zixuan Zhao, Clara Yieh Lin Chong, Ruochii You, Hengjia Zhou, Dong Hua Seah, Wei Qiang Leow, Hong Kit Lim, Sukanya Shyamasundar, Kanishka Fernando, Fathima Farzana Kuthubudeen, Gillian Ng, Chor Yong Tay, Narayanan Gopalakrishna Iyer, Chin‐Ann Johnny Ong, Eliza Li Shan Fong   +16 more
wiley   +1 more source

Advancements in Carbon‐Based Piezoelectric Materials: Mechanism, Classification, and Applications in Energy Science

Advanced Materials, EarlyView.
Carbon‐based piezoelectric materials are systematically categorized based on their structural and functional properties. The mechanisms of stress‐induced charge transfer are elucidated, and their applications are explored across three key domains: piezoelectric catalysis for energy conversion and environmental remediation, piezoelectric biomedical ...
Mude Zhu, Qingyou Liu, Wai‐Yeung Wong, Linli Xu   +3 more
wiley   +1 more source

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties

Advanced Materials, EarlyView.
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang, Jordi Guillem‐Marti, Saurav Kumar, David S. Lee, Daniel Cabrerizo‐Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela‐Velasco, Analisa Murray, Stacey Gerben, Anindya Roy, Cole A. DeForest, Timothy Springer, Hannele Ruohola‐Baker, Jonathan A. Cooper, Melody G. Campbell, Jose Maria Manero, Maria‐Pau Ginebra, David Baker   +25 more
wiley   +1 more source

Intravasation‐On‐µDevice (INVADE): Engineering Dynamic Vascular Interfaces to Study Cancer Cell Intravasation

Advanced Materials, EarlyView.
Cancer metastasis begins with intravasation, a complex process involving cancer‐endothelial interactions. INVADE (Intravasation‐on‐µDevice), a biomimetic microfluidic platform enables high‐throughput analysis of intravasation under controlled conditions.
Fengtao Jiang, Yingqi Zhang, Guocheng Fang, Yao Wang, Alexander Dupuy, Jasmine Jin, Yi Shen, Khoon S Lim, Yinyan Wang, Yu Shrike Zhang, Ann‐Na Cho, Hongxu Lu, Lining Arnold Ju   +12 more
wiley   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening

Advanced Materials Technologies, EarlyView.
This novel microfluidic organ‐on‐a‐chip (OoC) platform enables cost‐effective, high‐throughput in vitro modeling. With vertical compartmentalization and gravity‐driven flow, it eliminates porous membranes and external pumps. Successfully generating intestine, cartilage, and tendon models, this study demonstrates drug responses, including 5‐fluorouracil
Xavier Barceló, Pooya Azizian, Blanca del Pozo, Marta Olle‐Monge, Lourdes Gombau, Joan M. Cabot   +5 more
wiley   +1 more source