Results 301 to 310 of about 351,513 (313)

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

APOBEC3B/ASF1B-TGF-β signaling axis promotes epithelial-mesenchymal transition in HPV-positive oropharyngeal cancer. [PDF]

J Dent Sci
Hsieh MS, Sheen CC, Hsu TN, Yeh CT, Chang WJ, Wu YC.   +5 more
europepmc   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

The Role of lncRNAs in the Epithelial-Mesenchymal Transition in Cervical Cancer: A Narrative Review. [PDF]

Asian Pac J Cancer Prev
De Sousa LR, Sousa EDLS, Palmeira ACDC, Palmeira MS, Barbosa EDS, Da Silva MGOP, Da Fonseca SSS, Teixeira EB, Pinho JD, Andrade MS.   +9 more
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Epithelial-Mesenchymal Transition in Human Alveolar Cells Exposed to Indium Chloride. [PDF]

J Appl Toxicol
Kimura E, Ahmed S, Chen H, Hiraku Y.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Prognostic Implications of Exosomal miRNA Networks Regulating TGFβ1-induced Epithelial-Mesenchymal Transition Signature in Oral Squamous Cell Carcinoma. [PDF]

Cancer Genomics Proteomics
Kim M, Kim SI, Eun YG, Choi N, Kim J, Lee YC.   +5 more
europepmc   +1 more source

RHOJ-induced chemotherapy resistance through epithelial-mesenchymal transition in drug-tolerant persister cells of head and neck cancer. [PDF]

Transl Oncol
Ling HH, Huang CM, Hsieh MS, Yadav VK, Fong IH, Kuo KT, Yeh CT, Tsai JT.   +7 more
europepmc   +1 more source

RBMX2 links <i>Mycobacterium bovis</i> infection to epithelial-mesenchymal transition and lung cancer progression. [PDF]

Elife
Wang C, Peng Y, Yang H, Jiang Y, Khalid AK, Zhang K, Xie S, Bermudez L, Yang Y, Zhang L, Chen H, Guo A, Chen Y.   +12 more
europepmc   +1 more source